ID   A0A3Q3LZH2_9TELE        Unreviewed;       984 AA.
AC   A0A3Q3LZH2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Solute carrier family 12 member 3-like {ECO:0000313|Ensembl:ENSMAMP00000018512.2};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000018512.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000018512.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   AlphaFoldDB; A0A3Q3LZH2; -.
DR   STRING; 205130.ENSMAMP00000018512; -.
DR   Ensembl; ENSMAMT00000018990.2; ENSMAMP00000018512.2; ENSMAMG00000012439.2.
DR   GeneTree; ENSGT00940000155044; -.
DR   InParanoid; A0A3Q3LZH2; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR002948; SLC12A3.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF97; SLC12A10.3 SOLUTE CARRIER FAMILY 12 (SODIUM_POTASSIUM_CHLORIDE TRANSPORTERS), MEMBER 10, TANDEM DUPLICATE 3 ISOFORM X1-RELATED; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 2.
DR   PRINTS; PR01230; NACLTRNSPORT.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        129..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        162..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        208..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        332..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        499..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        546..562
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          134..593
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          615..764
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          768..983
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          77..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   984 AA;  109795 MW;  B8FC4B7892F9DA9F CRC64;
     MGQLKSKHHI PCVHFSANDE GLPRYASHQF DTCNQKQDGN LQIPPTIVVS DGSRMDLRRS
     SFYSTLDLVP QLDNYTSTLP HQQSRSRPSL EALRKVPHTT TDSEVSSLPV IDSGNEESKS
     LQEKAPVRFG WVTGVMIRCM LNIWGVILFL RLSWIISEAG IMLTSVIILM SATVTSVTAL
     SISAIATNGR VISGGAYFMI SRSLGPEIGG PIGVVFSFAN ALACALNTVG FAEVVVKLMM
     EFGIVMVDEI NDIRIVGVIT VTILLLISLA GMEWESKTQI LFFIVLMVSF SNYLVGTIIP
     PSPEKQAQGI FGYHSEIFLA NLKPDWRLGN NFFQTFAIFF PSAIGILSGA NISGDLKDPA
     TAIPKGTLMA IFWTTVSYLG ISFTLGSCVI RDASGNISDA LTGNITDGCV GCNLGWNFTE
     CTLSKSCQYG LANDSKVLGQ ISGFYYLITA GVFAASLSSA LGFLVSAPKV FQCLCRDKIY
     PYIGFFAKGY GKNDEPLRAY ILCYVIAVSP LCLISNFFLC SYSLINFSCF HASITNSPGW
     RPSFHYYSKW TALFGAVISV VLMFLLTWWA ALITFSIIFF LFGYVNYTKP TAVVSRLSSS
     FRPQCLVLTG PPNQRPALVD FVASFTKHIS LMICGDIIME EERQTRPQDA TDLLVKWMNK
     RKVRSFYTPL SADGLRAGAR NLLQASGLGK LKPNTLVLGF KSNWRESSPE SIEDYINTIY
     DTFDSNYCLC ILRMMDGLDI FDQFDFEVNQ GFESDESVEN DHQSPVRQSV EDISDKGDSD
     QIKTVFQSDQ GKKTIDVYWI ADDGGLTLLV PYLLTRRKLW RSSKVRVFIV GDEQNMDERR
     KEMIALLKRF RLDFNDVIVM TDSEKRPHSK NLSRFLDSVA PFRLWDEQQE GTLAQEFREN
     APCKISDKQF EAFRLKTERK VRLNEIIRRN SQHAALVLVS LPVPQSDCPS ALYMAWLDTL
     TCGLHCPAVL IRGNQQNVLT FYCQ
//