ID A0A3Q3M0T6_9TELE Unreviewed; 1139 AA.
AC A0A3Q3M0T6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b {ECO:0000313|Ensembl:ENSMAMP00000014819.1};
GN Name=ASAP1 {ECO:0000313|Ensembl:ENSMAMP00000014819.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000014819.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000014819.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q3M0T6; -.
DR Ensembl; ENSMAMT00000015229.2; ENSMAMP00000014819.1; ENSMAMG00000009940.2.
DR GeneTree; ENSGT00940000158547; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08848; ArfGap_ASAP1; 1.
DR CDD; cd07641; BAR_ASAP1; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR CDD; cd11965; SH3_ASAP1; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR037928; ASAP1_BAR.
DR InterPro; IPR038016; ASAP1_SH3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF2; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 310..402
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 426..547
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 587..622
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1077..1139
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 703..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..797
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..822
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..1034
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 126426 MW; 5CE5BC6A82D9B5BE CRC64;
MLSRGRMPDQ ISVSEFLSET TEDYNSPTTS SFTTRLQSCR NTVNVLEEAL DQDRTSLQKV
KKSVKAIYSS GQDHVQNEEN YAQALDKFGS NFISRDNPDL GTAFVKFSSL TKELSALLKN
LLQSLSHNVI FTLDSLLKGD LKGVKGDIKK PFDKAWKDYE AKFTKIEKEK REHAKQHGMI
RTEITGAEIA EEMEKERRLF QLQMCEYLIK VNEIKTKKGV DLLQNLIKYY HAQCNFFQDG
LKTADKLKQY IEKLAADLYN IKQTQDEEKK QLTALRDLIK SSLQLDQKED SQSKQGGYSM
HQLQGNKEFG SEKKGYLLKK SDGLRKVWQR RQCSVKGGIL TISHATSNRQ PVKLNLLTCQ
VKPSTEDRKC FDLISHNRTY HFQAEDEQEF VIWISVLTNS KEEALNMAFR GEQSGGGEDG
LEDLTKAIIE DVLRMPGNEI CCDCGAADPK WLSTNLGILT CIECSGIHRE MGVHISRIQS
MELDKLGTSE LLLAKNVGNS SFNEIMEGNL TTPSPKPTPS SDMTVRKEFI NAKYVDHKYA
RKTCTSASAK MIELFEAVQS RDLLALIQVY AEGVELMEPL PEAGPEAGET ALHYSVRTAD
QTSLHLVDFL VQNSGNLDKQ TEWGNTALHY CCMYEKPECL KLLLRGKPAT DITNQNGETA
LDVARRLRNT QCEEALVQAA EGKFNPHIHV EYEWSLRLEE MDESDDDLDD KPSPIKKDRS
PRPQSFCHSS SLSPHDKLSL PGFISQRDKQ QRLSYSAFTN QMYSASTDLT SSPVADGPPL
PPRNLGKATP PSGPPSTLTP GASSTLSKKR PPPPPPGHKR TLSDPPSPLS HSPHSKGCLT
GGSDSTPPPV SKMSPVSNKF EGIPQQQSTT SSNTKSTLGP RVLPKLPQKV ALRKIDTIHH
PSMDKPALPP EVFQKSPPAS DTQLKSSLTD RPQVGDLPPK PHPSELPPKP GELPPKPQLS
DLPPKPQLGD LPPKPQLKDL PPKPHLADIP PKPGTAESAP RPPPGETTQR PQVQPPPPPQ
IQTQPQPQSP PQDSPSPNQQ ANITTPPQQP TEDTNGTPAG TAETPVPLPR KLNTGKIKAR
RVKTIYDCQA DNDDELTFAE GEVIIVTGEE DQEWWIGHIE GDPERKGVFP MSFVHILSD
//
