ID   A0A3Q3M3H8_9TELE        Unreviewed;       450 AA.
AC   A0A3Q3M3H8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000021513.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000021513.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR   AlphaFoldDB; A0A3Q3M3H8; -.
DR   Ensembl; ENSMAMT00000022058.2; ENSMAMP00000021513.2; ENSMAMG00000014395.2.
DR   GeneTree; ENSGT00940000164351; -.
DR   InParanoid; A0A3Q3M3H8; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   NCBIfam; TIGR00840; b_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF99; SODIUM_HYDROGEN EXCHANGER; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 2.
DR   PRINTS; PR01084; NAHEXCHNGR.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU003722};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003722};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..450
FT                   /note="Sodium/hydrogen exchanger"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030081344"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        135..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        166..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        250..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        356..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        381..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          51..338
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   DOMAIN          353..407
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   450 AA;  49608 MW;  B580086759BF6EB7 CRC64;
     GCLVCVYVCV CVCVCVCSPP PLHNLCPFIS PSLSLPLSQH GSRVMGAPWT LLLFLSALGC
     LGRVPAVVPE SCLLIMVDLL VGGVIYGVRH SAPPTLSADA FFLFLLPPIV LDVGYFLPGR
     LFFENLGTIL WTFRYAVLGT LWNVLGIGLS LYGVCLLTPS SLGDVSLLHC LLFGSLIAAV
     DPVAVLSVFQ EMHVNEQFHI LVFGQSLLSD TVTVVLYRLF ESFLRLPSVL GVVVLLGACR
     VVLVGLGGLC VGAQVIAPLF VFLYSYLSYL TSEMLHLSGI MAIVTCAVTM KQYVEATVSE
     HSNISIQYFL RMWSSVSETL IFNFLGVSTI QEVHMWSWAS GSFKNHSCTL DIDQFIIAYC
     GLRGAICFPL VFLIDDFPKK RLFITTTIVV ILFTVFAQGM TMKPLVELLD VKRKKRALPT
     VSEEIHNIQH TEMDFGVYNT KSHHIWKHKT
//