ID A0A3Q3M7R9_9LABR Unreviewed; 732 AA.
AC A0A3Q3M7R9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Inhibitor of nuclear factor kappa B kinase subunit epsilon {ECO:0000313|Ensembl:ENSLBEP00000016460.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000016460.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000016460.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q3M7R9; -.
DR STRING; 56723.ENSLBEP00000016460; -.
DR Ensembl; ENSLBET00000017402.1; ENSLBEP00000016460.1; ENSLBEG00000012699.1.
DR GeneTree; ENSGT00950000182937; -.
DR InParanoid; A0A3Q3M7R9; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.20.1270.420; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041309; TBK1_CCD1.
DR InterPro; IPR041087; TBK1_ULD.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF10; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF18394; TBK1_CCD1; 1.
DR Pfam; PF18396; TBK1_ULD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 13..318
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 42
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 732 AA; 83363 MW; E622B237B17156C7 CRC64;
MTGITASTTN YLWSIQDVLG QGATASVYKA RNKRSGELVA VKVFNTMSYN RPHDVQMREF
EMLRKLSHSN IVRLFAVEEM PSKNKVLVME YCSGGSLLSL LEEPENAFGL PETEFLIVLQ
CVVQGMNHLR ENGVVHRDIK PGNIMRQVGE DGKSVYKLTD FGAARELEDD EKFLSIYGTE
EYLHPDMYER AVLRKPHQKS YGVSVDLWSI GVTFYHTATG SLPFTPYGGP RRNKPTMFKI
TTEKPMGAIA GIQRVADGPI EWSYGLPHSC QLSQGLTVQL VPVLAGILEA DQERCWGFDQ
FFTATTDILQ RQPVHLFSLQ QAQAHCIYIH HYNTVSVFFE EVASQTGIGV QLQHLLYLGH
DLPLEGNMKV VNLPSTSRAQ PLILLSCGPE ANPSLPFREP ETPVIPSKFD VVADYHFTKV
TVGVVHQYLR MVKLLHSHRE LLLQGYYSYM MRLRRECGEA MHSIAMITVR LQSCLSVEHR
LHTLGQHTSE NQGSGDGNEK LQLVHQHLPI YATGIQEFQN RLDHLQIEQA KLAETLANDK
SCQKMEMLLQ KITVIHQHYR KDKLIGKLSY NDEQIHKFEK IHLSTHIKRV KSLFRDDCVQ
RYKELLASAR TWSSVLLEKQ TRLQDFGSFS TGLLADLEMN NQRQNKALDR ILSGLKPGRG
AQQSTVAPRD KDQMVFRMHH LKEEMEILVQ ELQFNNSVIE RSVSPCQLDI HLVVRTFGLL
LCFCFCSVVW EQ
//
