ID   A0A3Q3M7U7_9TELE        Unreviewed;       721 AA.
AC   A0A3Q3M7U7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=G protein-coupled receptor kinase interacting ArfGAP 2a {ECO:0000313|Ensembl:ENSMAMP00000023208.1};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000023208.1, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000023208.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q3M7U7; -.
DR   Ensembl; ENSMAMT00000023803.2; ENSMAMP00000023208.1; ENSMAMG00000015537.2.
DR   GeneTree; ENSGT00940000156383; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR047161; GIT-like.
DR   InterPro; IPR032352; GIT1/2_CC.
DR   InterPro; IPR022018; GIT1_C.
DR   InterPro; IPR013724; GIT_SHD.
DR   PANTHER; PTHR46097:SF4; ARF GTPASE-ACTIVATING PROTEIN GIT2; 1.
DR   PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF12205; GIT1_C; 2.
DR   Pfam; PF16559; GIT_CC; 1.
DR   Pfam; PF08518; GIT_SHD; 2.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00555; GIT; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          1..124
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REPEAT          166..198
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          382..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          535..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          437..464
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        402..418
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  80468 MW;  9DBCFF58337BEBDB CRC64;
     MSKRLRNTEV CADCSVPEPR WASVNRGVLI CDECCSVHRS LGRHSSQVRH LTHTPWPPTQ
     LQMVQTLYSN GANSIWEHSL LDPASVMSGK RKANPQDKLH PNKSEFIRAK YQMLAFVHRM
     PCREDDNLTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGNTP LHVAAKAGQV
     SQAELLTVYG ADPGAPDSNG KTPIDYAREA GHHDLADRLV EIQYELTDRL AFYLCGRKPD
     HKNGQHFIVP QMADSSLDLS DLAKAAKKKL QSLSNHLFEE LAMDVYDEVD RRETDAVWLT
     TQNHSTLVTE TTVVPFLPVN PEYSSTRNQG RQKLARFNAH EFATLVIDIL SDAKRRQQGN
     SVASPKDNVE LILKRVALRH CSDSQDNDQP DYDSVASDED TDQEVSSSKG DRTKSLDSDL
     SDGPITMHEY LEVKNALSAS EVKIQQLMKA NNNLSDELRL MQKKTERGAF VTTSSSLPSF
     PSTLSWSKDE SAQKASKLEK QSSMPESDYD NTFNDSEIDD SGLCRRGRLR STGWLGEGSS
     VPELDDLEME SDPTLPSTED VIRKTEQITK NIQELLRAAQ ENKHDRPCER EGVRRLRHSL
     GCFSTLVPWA EKAPPSLQTL SLRSPDPTSC FIPCSERIHV AVTEMAALFP KKPRSETVRS
     SLRLLTSSAY RLQSECRKAV SSDGCPGPDM QLVTQQVIQC AYDIAKAAKQ LVTVTTKENT
     N
//