ID   A0A3Q3MA22_9TELE        Unreviewed;       191 AA.
AC   A0A3Q3MA22;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Gremlin 2, DAN family BMP antagonist a {ECO:0000313|Ensembl:ENSMAMP00000024218.2};
GN   Name=GREM2 {ECO:0000313|Ensembl:ENSMAMP00000024218.2};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000024218.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000024218.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q3MA22; -.
DR   STRING; 205130.ENSMAMP00000024218; -.
DR   Ensembl; ENSMAMT00000024834.2; ENSMAMP00000024218.2; ENSMAMG00000016284.2.
DR   GeneTree; ENSGT00940000154209; -.
DR   InParanoid; A0A3Q3MA22; -.
DR   OrthoDB; 5347549at2759; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   PANTHER; PTHR15283; GREMLIN 1; 1.
DR   PANTHER; PTHR15283:SF2; GREMLIN-2; 1.
DR   Pfam; PF03045; DAN; 1.
DR   SMART; SM00041; CT; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..191
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030081405"
FT   DOMAIN          78..184
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|SMART:SM00041"
FT   REGION          23..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   191 AA;  21824 MW;  D0A39A01542B4806 CRC64;
     MLWKITIPVI LAGVLCITAE TKKPRPQGSI PSPNKTKGNL SSERHHRLLQ QKPEVLSSSR
     EALVVTERRY LRRDWCKTQP LRQTISEEGC RSRTVVNRFC YGQCNSFYIP RHMGPSSGQS
     RGQASGSGRK NHNKGQEPFQ SCSFCRPHRI TQLTVQLDCP DLQPPFRHRK VQRVKQCRCM
     SVDVSVAMQT H
//