ID A0A3Q3MFK5_9LABR Unreviewed; 403 AA.
AC A0A3Q3MFK5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Lysosomal acid phosphatase {ECO:0000256|ARBA:ARBA00039422};
DE EC=3.1.3.2 {ECO:0000256|ARBA:ARBA00012646};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000019035.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000019035.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000256|ARBA:ARBA00004227}.
CC Lysosome membrane {ECO:0000256|ARBA:ARBA00037852}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00037852}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00037852}.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR AlphaFoldDB; A0A3Q3MFK5; -.
DR STRING; 56723.ENSLBEP00000019035; -.
DR Ensembl; ENSLBET00000020065.1; ENSLBEP00000019035.1; ENSLBEG00000014635.1.
DR GeneTree; ENSGT00940000158446; -.
DR InParanoid; A0A3Q3MFK5; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR11567:SF180; LYSOSOMAL ACID PHOSPHATASE; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..403
FT /note="Lysosomal acid phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018781838"
FT TRANSMEM 375..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 403 AA; 45936 MW; 344B8191742EC37B CRC64;
MVSASSLFLI TLSFLCGEAV AQGKLVYVTV LFRHGDRSPV KAYPTDPYQE SAWPQGFGQL
SQEGMRQHFN LGQFFRNRYK GFLNESYERH EISVRSTDYD RTLMSAEANL AGLYPPTGQQ
VFKTDLQWQP IPVHTVPQSE EKLLSFPRHD CPRYELLMTE TEQAEEFLNV TTSYQDFIEF
VRDKTGLNKT DVESVWSVHD TLFCESRHNK SAPDWVTPEV MQKLRFLKDF GFKVFFGVHN
PQEKSRLQGG ILLGEIVQNI SKMAVPDPKN KLKLMMLSAH DTTVAALQWS LNVYNGKQPP
YASCHIFELY KDENGSASVL MFYRNDSSVE PYPVQLPGCS LHCPLEDFVR ITKPSISEDR
DKECQLPSER RDTEVIISLA LSGCLLLLLI ALLLALFVGR KSQ
//
