ID A0A3Q3MH39_9TELE Unreviewed; 2106 AA.
AC A0A3Q3MH39;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000024462.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000024462.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR Ensembl; ENSMAMT00000025093.2; ENSMAMP00000024462.2; ENSMAMG00000016385.2.
DR GeneTree; ENSGT00390000013680; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF4; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1336..1661
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1697..2095
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 296..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1950..1983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..540
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..995
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1950..1974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2106 AA; 232464 MW; 351E4EC2BD5268F0 CRC64;
MSSCFVPNGA SLEDCHSNLF CLADLTGIKW RRFVWQGPTS SPILFPVTEE DPILCSFSRC
LAADVLSVWR RHHTPGRREL WLFWWGDDPS FAELIHNELS SEEDGEWESG LSYECRTLLF
KAIHNLLERC LMNRGFVRIG KWFVKPYQKD EKTINKRCHL SCAFTFFVHG DSNVCTSVEI
AQHQPLQCLS EEHLSLAQQS SSPLQVILSP YGLNGTLTGQ AFKMSDHPTQ KLIEEWRQFY
PISPNPKEVQ EDKMEDTDWE DDSLAAVEVL VAGVRMVYPS CLVLLPLSDL PAVAPQGSAN
TSGSLCGAQQ GQAAHRDPAM SSVTLTPPTS PEEAQTNYQP AQRWLKLSSA SDGYSSDNTL
HGGKIPRRLA SQMVESVWQE YNINRTGNKR KLTTLTNGTC EEESHKTGLW DFVEPTHRLH
CNCSRHKNQK QRSSSTSGHP PSSGQPAQPT PKHKLGEKLE KGEKQQKRPQ TPFHHRNSVS
EESSLEPQTQ RLCLRSQEEG SYPSLHHVDT VPSKAPTLHT HGPPADLVGS PPPPPLSPHP
CDHVDGDMTP SGMKTSSTPV HQGFYPPSVE PCLLPQKGSS EEPQLENMRM PLPFPPPYSE
TLEPTVFVGS AINPNEDSTH NPWKYFNLPR KKATNFPTPQ LPVDKMREDS GGGGVTERVS
QELIKTYAQR RNSHLASTSV DEEHSNEPDP YAFIEGDEEF SFTEKKDKPG AEREGNKKHK
NLFPLSVLYI GKSNAWSWVS YTVLFCCADG QGPSGSKPST STSLIHENDL AVSYSDLDKI
FNSDEDELAP GSKRAGVSTE DKYGCKEIKP ATLDPLSCIS SADLHQMFPT PPSLEQQGYS
PMNSGSKDSL EAAAGVTLLD GSQLNSHFKM EVEEGFCSPK PSEVKDFSFV YKPETCQPFI
GCSMYAPLKT LPSQCLLPIK LPEDCVYTPS WTLGKMELIN VPSVEPDYSQ TYTPQTHTPF
MSSSAPPSNS GTGILPSPAT PRFSVPTPRT PRTPRTPRGP SSVQGSLKYD NSDLYSPAST
PSTCRPLSSV EPATVPSIPE AHSLYVTLIL SESVMNLFKD CNFDSCCVCV CNMNIRGADV
GVYLKDNGEA QYPCTCGFSA VINRRLGQLA GLFLEDELDM VGRGSDASRD TERCFEELRA
STTHKAGSLK EKPPDELILL LQDQCTNPFA PMAGVDYPKP SSAPCSFLRV GERDCYNDCY
MALEHGRQFM DNMSGGKVDE TLVKSTCLHQ WPKFKSADMS KLFSQDILRV LLSLQPVLQD
TIQKKRSVRS WGVQGPLTWQ QFHKMAGRGS YGTDESPEPL PIPTFLVGYE HDFVVLSPFG
LPYWEKLLLD PFGSQRDVGY VIICPENEAL LHGAKTFFKD LSVIYEACQL GQHRPICKSH
PEGILKVRTT EGRSMTEQPL SDWFLKMAAR DGNNEAFNKL KLFAQVCRYD LAPYLSEQSL
DSSLLSQRSP AMASSSSQTS SSSSTSSGPQ STNTTSSSTS SAQVNSTPPS SGSQTIGGLA
SSKPSSFSMY GTAGLQGSTS QNGPQSNPQG AGGLAENGPS ANQPQGPTET PESTMERDKV
GKPTDGESHA VSYPPAIVVY LVDPFSYEDA DKEVHSSTYT LGLLRCYMEM LQFLPAHIRN
AVSVQIVPCQ YLLQPVHSGE RHLYNQHLKS LAFSVFTQCR RPLPNSTNFK TLTGFGPGLA
IDMALKNPER PECLRLYTPP FILAPVKDKQ TELGETFGEA SQKYNVLFVG YCLSHDQRWL
LASCTDQHGE LLETCIISID VPNRARRKKG SARRLGLQKL WEWCLGLVQV TSLPWRVVIG
RLGRMGHGEL RDWSILLSRR NLQSLSKRLK ETCRMCGISA ADTPSILSAC LVAMEPQGSF
VIMPDSVSTG SVFGRSTTLN IQTSQLSTPQ DTSCTHILVF PTSAMVQVNT NTSEPIDINF
NPINPDGSDG MGIFELFDND MVDPDLINIL PNSPTTSPVH SPGSHYQQGG DGSKGQSADR
MESHEEALNI LQQPMALGYF VSTAKAGPLP DWFWSACPQA QNQCPLFLKA SLHLHVSSVQ
SDELLHSKHS HPLDSNHTSD VLRFVLEQYN ALSWLTCDPA TQDRRSCLPV HFVVLTQMYN
FIMNML
//
