ID   A0A3Q3MIR9_9TELE        Unreviewed;       995 AA.
AC   A0A3Q3MIR9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Mtr4 exosome RNA helicase {ECO:0000313|Ensembl:ENSMAMP00000025022.2};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000025022.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000025022.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q3MIR9; -.
DR   Ensembl; ENSMAMT00000025669.2; ENSMAMP00000025022.2; ENSMAMG00000016753.2.
DR   GeneTree; ENSGT00940000156183; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18024; DEXHc_Mtr4-like; 1.
DR   CDD; cd13154; KOW_Mtr4; 1.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 2.
DR   Gene3D; 2.40.30.300; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR048392; MTR4-like_stalk.
DR   InterPro; IPR025696; MTR4_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21408; MTR4-like_stalk; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT   DOMAIN          97..253
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          327..531
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          300..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   995 AA;  112429 MW;  1A13EC60768D275A CRC64;
     MADAFGDSLF SVFDDEQQTT TNKKIPTPVA PEIGCFVYFS LAEFMPQVKV EQVETVEGCS
     HEVALPASDE YKPLKPRVGK AAKEYPFILD PFQREAILCI DNNQSVLVSA HTSAGKTVCA
     EYAIALALRE KQRVIFTSPI KALSNQKYRE MYEEFQDVGL MTGDVTINPT ASCLVMTTEI
     LRSMLYRGSE IMREVAWVIF DEIHYMRDAE RGVVWEETII LLPDNVHYVF LSATIPNARQ
     FAEWICHLHK QPCHVVYTDY RPTPLQHYIF PAGGDGLHLV VDENGDFRED NFNTAMQVLR
     DTGDSGSSGG GKWDPKGRKG GTRGPSSVFK IVKMIMERNF QPVIIFSFSK KDCEAYALQV
     AKLDFNRDDE KRLVEEVFNN AVDCLSDEDK KLPQVEHVLP LLKRGIGIHH GGLLPILKET
     IEILFSEGLL KALFATETFA MGINMPARTV LFTSARKYDG KNHRFITSGE YIQMSGRAGR
     RGMDDRGIVI FMVDEKMSPA VGKQLLKGSA DPLNSAFHLT YNMVLNLLRV EEINPEYMLE
     KSFYQFQHYR ALPGVVEKIK KLEEQYHAIE IPNEESVVTY FKIRQQLAKL GKEIQEFIQK
     PKYCLPFLQP GRLVKVKNED ADFGWGVVVN FCKKSNVKTS TDSDPLYVVE VLVHCSKDSV
     KDAATEAAKP AAPGETGEMQ VVPVMLHLLT AISSVRLYIP KDLRPFDNRQ LMLKSIQEVQ
     KRFPDGVPLL DPIDDMGIKD PALKKVIQKV EAFEHRMYSH PLHSDPNLES VYSLCEKKAL
     IAADVRAAKR ELKKARTVLQ MDKLKCRKRV LRRLGFASPS DVIEMKGRVA CEISSADELL
     LTEMIFNGLF NDLTVEQATA LLSCFVFQEN ASEMPKLTEQ LAAPLRQMQE CARRIAKVSA
     DAKLEVDEET YLNQFKPHLM DVVYAWANGA TFAQICKMTD VFEGSIIRCM RRLEEVLRQM
     CSAAKAIGNT ELENKFAEGI TKIKRDIVFA ASLYL
//