ID A0A3Q3MLD5_9TELE Unreviewed; 908 AA.
AC A0A3Q3MLD5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Xeroderma pigmentosum, complementation group C {ECO:0000313|Ensembl:ENSMAMP00000023641.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000023641.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000023641.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR AlphaFoldDB; A0A3Q3MLD5; -.
DR STRING; 205130.ENSMAMP00000023641; -.
DR Ensembl; ENSMAMT00000024250.2; ENSMAMP00000023641.2; ENSMAMG00000015829.2.
DR GeneTree; ENSGT00390000005194; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018026; DNA_repair_Rad4-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR NCBIfam; TIGR00605; rad4; 1.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT DOMAIN 592..644
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 646..705
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 712..786
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..140
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..435
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 102731 MW; 8E8AD7A72F62AF2A CRC64;
MAKSRKCAET KKVKRTVKAE SSGARAGARV KDAAGGITET EDKLERKVKP RSRYSTRQAA
GITSSSASTN ITAVKTSKYF QSPAKEEETH SEDDFDMETS AKPVVTVNTR EPEKEEEEEE
EDEDSEEDEG DWEEVEELAE PLGPVEPPEP ILPSQPVEIE IETPEVRKKQ KKQAEFETYL
RRMMNRYKKD VLEDTHKVHL MCLIASGMFR NRLCSEPDLL AVTLSLVPAR FTIVAKERMD
ENYLSGLLKW CVATFTLNPS LPCEERPDPQ ALLERRLASL SARNHQEMTH LFLLVLRSLQ
LFCRLVLSLQ PIPLKPPSGA RTSAGTSGKS DTSQKTSETN SPEPKVSPGT KRPAGSRESK
GARGGKKAKK KEVKEEDEDE EENAVISGRQ KPKNLKRRSV ASKVSYKEES NSEGEEGLTD
EEEFQLTSEE ASEDSEGEDK STKEKRRSGG TKKQVKEDKD CEDEEDSDEG EKVQNNRTKQ
RSAKKMDGPG NDEWLEVYLQ TGSSWVCMDV EHGVGMPHLC SENATAPVTY VVSVDGDGFV
KDLGRRYDPT WMTSSRKRRV DEDWWEETLE PFLGPEDNRD IKEDKELQNK LLNKPLPVSI
VEYKNHPLYA LKRHLLKYEA IYPPTAAVLG YCRGEPVYSR DCVHTLHSRD TWLKEARTVR
LGEEPYKMVK GFSNRSRKAR MMSELKNEND LPLFGEWQTE EYQPPIAVDG KVPRNDYGNV
YLFKPCMLPV GCVHIRLPNL HRVAKKLNME AAPAVTGFDF HGGYSHAVTD GYIVCEEHEE
VLRAAWVEEQ ELQKQKEKEK KEKRAVSNWT LLVKGLLIRE RLKQRYSKKN QGLGSLAHGG
DTAGFSSDEE VVEGGSPGAK TASETLAMSW PQNRQTEEEG GSSNRLKKKT TKREKRGQEK
HLFPFEKV
//
