ID A0A3Q3MN56_9LABR Unreviewed; 309 AA.
AC A0A3Q3MN56;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000021775.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000021775.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR AlphaFoldDB; A0A3Q3MN56; -.
DR Ensembl; ENSLBET00000022939.1; ENSLBEP00000021775.1; ENSLBEG00000016708.1.
DR GeneTree; ENSGT00390000014786; -.
DR UniPathway; UPA00575; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF2; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 45..309
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 309 AA; 35248 MW; 78866ECD8B371EDA CRC64;
MPVTSDVLTE ELRREAAGKV EDRSEPAAAE QTKKNFGVLC DERGYLDQVE YILQHGRRKG
DRTGTGVLSV FGTQARYSLR GLHSITADFY KARVLLWKLK RVKIWDANGS RDFLDNLGFT
EREEGDLGPV YGFQWRHFGA EYTNMHADYT GQGVDQLQSV IDTIKKNPED RRIIMCAWNP
KDLPSMALPP CHALCQFYVC DGELSCQLYQ RSGDMGLGVP FNVASYALLT YMIAHITGLK
PGDFVHTLGD AHVYVNHIEP LKTQLQREIR PFPTLKILRR VERIDDFRAE DFEICDYNPH
PSIKMQMAV
//
