ID   A0A3Q3MRR7_9TELE        Unreviewed;       914 AA.
AC   A0A3Q3MRR7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Catenin alpha-2 {ECO:0000256|ARBA:ARBA00023806};
DE   AltName: Full=Alpha N-catenin {ECO:0000256|ARBA:ARBA00029822};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000027602.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000027602.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC       {ECO:0000256|ARBA:ARBA00004536}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004413}. Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC       {ECO:0000256|ARBA:ARBA00008376}.
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DR   AlphaFoldDB; A0A3Q3MRR7; -.
DR   STRING; 205130.ENSMAMP00000027614; -.
DR   Ensembl; ENSMAMT00000028316.2; ENSMAMP00000027602.2; ENSMAMG00000018570.2.
DR   GeneTree; ENSGT01030000234543; -.
DR   InParanoid; A0A3Q3MRR7; -.
DR   OrthoDB; 2875365at2759; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.250.2510; -; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR001033; Alpha_catenin.
DR   InterPro; IPR006077; Vinculin/catenin.
DR   InterPro; IPR000633; Vinculin_CS.
DR   PANTHER; PTHR18914; ALPHA CATENIN; 1.
DR   PANTHER; PTHR18914:SF23; CATENIN ALPHA-2; 1.
DR   Pfam; PF01044; Vinculin; 1.
DR   PRINTS; PR00805; ALPHACATENIN.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 4.
DR   PROSITE; PS00663; VINCULIN_1; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT   REGION          876..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        876..892
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   914 AA;  101606 MW;  08C9B1BEF46EDC99 CRC64;
     MISHLQTMTT ATSPILLKWD PKSLEIRTLT VERLLEPLVT QVTTLVNTSN KGPSSKKKGR
     SKKAHVLAVS VEQATQNFLE KGEQIAKDSQ DLKEELIAAV EDVRKQGETM RIASSEFADD
     PCSSVKRGTM VRAARALLSA VTRLLILADM ADVMRLLAHL KIVEEALEGV KNATNEQDLA
     NRFKEFGKEM VKLNYVAARR QQELKDPQCR DEMAAARGAL KKNATMLYTA SQAFLRHPDV
     AATRANRDYV FKQVQEAIGG ISSAAQATSP TDEKHGHAGI GELAAALNEF DNKIILDPLT
     FSEARFRPSL EERLESIISG AALMADSSCT RDDRRERIVA ECNAVRQALQ DLLSEYMNNT
     GRKEKGDPLN SAIDKMTKKT RDLRRQLRKA VMDHISDSFL ETNVPLLVLI EAAKSGNEKE
     VKEYAQVFRE HANKLVEVAN LACSISNNEE GVKLVRMAAT QIDSLCPQVI NAALTLAARP
     QSKVAQDNMD VFKDQWEKQV RILTEAVDDI TSVDDFLSVS ENHILEDVNK CVIALQERDV
     DTLDRTAGAI RGRAARVVHI INAEMENYEP GVYTERVLES IKLLSETVMP CFAEQVEVAI
     EALSTNPPQP FEENEFIDAS RLVYDGVRDI RKAVLMIRTP EELEDDSDFE QEDYDTRSRT
     SIQTEDDQLI AGQSARAIMA QLPQEEKAKI AEQVESFRQE KCKLDAEVAK WDDNGNDIIV
     LAKQMCMIMM EMTDFTRGKG PLKNSSDVIN AAKKIAEAGS RMDKLARAVA DQCPDSACKQ
     DLLAYLQRIA LYCHQLNICS KVKAEVQNLG GELIVSGVSL DSATSLIQAA KNLMNAVVLT
     VKASYVASTK YQKVYGTAAV NSPVVSWRMK APEKKPLVKR EKPEECQTRV RRGSQKKHIS
     PVQALSEFKA MDSF
//