ID A0A3Q3MTJ6_9LABR Unreviewed; 1067 AA.
AC A0A3Q3MTJ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSLBEP00000024205.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000024205.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000024205.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q3MTJ6; -.
DR Ensembl; ENSLBET00000025459.1; ENSLBEP00000024205.1; ENSLBEG00000018426.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..276
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 391..678
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 692..808
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 808..1067
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 118632 MW; 693DE757714912A3 CRC64;
MPTNFTVVPV DNAGEAGNSA AAAEEGKPAS LGNIFQEEAE EENVQGLNSG DEGQGESSPF
INSDSDGDYY YEGKNMALFE EEMDSTPMVS SLLNKLANYT NLTQGVREHE EAEYEDGIQR
VAVRVPQMGT FIGVYLPCMQ NILGVILFLR LTWIVGTAGI LGSFAIVSMC CICTLLTAIS
MSAIATNGVV PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGSLYILGT MEILLLYIVP
TATVFKEGED EARLNNMRVY GTCCLLLMAL VVFVGVNVCL LGNRSLRNDK FGICAKTEVV
KNNTLTTELW SIFCDSKYPN ATCDPFFTNN NLTEIRAIPG LLSGVIKDNL WGEYAPAREP
IEKKSLVSEQ DPDTPTDTYK PYVFNDIATY FTLLVGIYFP SVTGIMAGSN RSGDLRDAQR
SIPIGTIMAI VTTSIIYMSC VVLFGACIEG VVLRDKFGYS VKKTPVIGVL AWPSPWVIVI
GSFFSCCGAG LQSLTGAARL LQAIARDGII PFLQAVWRFS LHDITKVFGH GKANGEPTWA
LLLTVGICEI GILIASLDAV APILSMFFLM CYLFVNLACA VQTLLRTPNW RPRFKFYHWT
LSFLGMSLCL SLMFISSWYY ALVPMVIAGC IYKYIEYRGA VKEWGDGIRG LSLNAARYAL
IRLEEVPLHT KNWRPQLLVF CKLNSDLEVK HPRLLSFTTQ LKAGNGLTII CSVLEGTYMT
REKDAKTGEQ SLKAAMVAER TKGFSHIVVS SDLRDGFSLL IQSAGLGGMK HNTVLMAWPA
GWKQAGDSSA RRNFIETVRE TTAAHQALLV AKNIDHFPSN QERQKEGTID VWWIVHDGGL
LMLLPFLLSQ HKVWRKCKMR IFTVAQMDDN SIQMKKDLQM FLYHLRLDAQ VEVVEMHDSD
ISAFTYEKTL MMEQRSQMLK QMQLSRTERE REAQLIHDRN TASHSTNEKA AGAPPDKVHM
TWTKEKLIHE KNKHREGMGV KDMFNMKPEW ENLNQSNVRR MHTAVKLNEV VVKNSQNSQL
VLLNMPGPPS NKKGHENYME FLEVLMEGLD RVLLVRGGGR EVITIYS
//