ID A0A3Q3MTQ3_9LABR Unreviewed; 841 AA.
AC A0A3Q3MTQ3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000024275.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000024275.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR AlphaFoldDB; A0A3Q3MTQ3; -.
DR STRING; 56723.ENSLBEP00000024275; -.
DR Ensembl; ENSLBET00000025530.1; ENSLBEP00000024275.1; ENSLBEG00000018582.1.
DR GeneTree; ENSGT00940000156144; -.
DR InParanoid; A0A3Q3MTQ3; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44216; PROTEIN O-MANNOSYL-TRANSFERASE TMTC2; 1.
DR PANTHER; PTHR44216:SF3; PROTEIN O-MANNOSYL-TRANSFERASE TMTC2; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13432; TPR_16; 3.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 6.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..841
FT /note="dolichyl-phosphate-mannose--protein
FT mannosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018560261"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 245..317
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 492..525
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 526..559
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 605..638
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 642..675
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 676..709
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 778..811
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 351..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 94027 MW; D7964FB9E1F6415E CRC64;
MITELVCTAV AVGLYLNTLD AEFCYDDSRA IKTNQDLLPE TPWTNILYDD FWGTLLTHSG
SHKSFRPLCT LSFRLNYTLH GLRPWGYHLL NIILHALVTL LFTAFSRPLL GGGLWTVAGV
VGRADVGAAL FFLLSLLCYM RHCGLRRESR GPFQSQKCGG CSATLCWGWM LSSLWCAAAS
MLWKEQGVTV LAVSAVYDLF VFQRLRFRQV LLLLLGKNIS VLLSLGVLVS WGVLLLSARL
YWMGNKPPNF SNSDNPAADS PHFLTRTLTF LHLPAANAWL LLCPDKLSFD WSMDAVPLVR
SLADWRNLHT VAFYGGFILL ALIGLRSSNS KAKETNGKAC VANGKSITNG NGYHAPDTNH
NTDQGPPKTT INGSAGLHHY PPNTSLPPTE NLILFSLAIM FLPFIPATNL FFYVGFVIAE
RVLYIPSIGF CLLVATGARA LYIRLRTRGS KVLLLCFCAG LVLLNGLRTV QRNRDWSNEE
NLYKSGISVN PAKAWGNLGN VLKNQGKMAE AETAYRNALH HRGNMADMLY NLGLLLQENE
RFSEALHYYK LAIGSRPTLA SAYLNTGIIL MNQGSLDEAK RTFLTCADIP DENLKDPHAH
KSSVTSCLYN LGKLLHEQGQ QEEALSIYKE AVQKMPKQFA PHSLFNMMGE AYMRLNRLEE
AAHWYRESLR AKPDHIPAHL TYGKLLSIIG QKTEAEKFYL RAIQLDPTKG NCYMHYGQFL
LEQSRLGEAA EMAERAAELD RSEFDVVFSA AHMLRQANLN EAAERQYVRA ASLRPDYPAA
LMNLGAILHL NGKLPEAEAN YLRALQLKPD DVITQSNLRK LWNIMERQGL RIRQGVQNNN
P
//
