ID   A0A3Q3MUQ2_9TELE        Unreviewed;       895 AA.
AC   A0A3Q3MUQ2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000028492.1, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000028492.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q3MUQ2; -.
DR   Ensembl; ENSMAMT00000029233.2; ENSMAMP00000028492.1; ENSMAMG00000019182.2.
DR   GeneTree; ENSGT00940000158551; -.
DR   InParanoid; A0A3Q3MUQ2; -.
DR   OrthoDB; 534027at2759; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF22; ANOCTAMIN-7; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        279..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        358..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        433..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        480..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        522..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        657..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        707..731
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        789..810
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          41..268
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          271..832
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          845..895
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..872
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        873..895
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   895 AA;  102914 MW;  A8E60C94FBC6EAE7 CRC64;
     MKKRGEQMED ATTLIAMEMK PENNYGTITM NASVQPWDRN VFSDGSTRVD FVLVWEEPYS
     LHKEESTGVN PTHLKWREEF LNRLRNSGLL LEQKEVLQTK KKICFVLLST PWSVLCYYAE
     EIGLRAPLEV VTAPIVNWSE ELLSQLSLPS PLSQDVPNPP PDYYTCQFRA NKLERFLGSD
     NKDTFFKTTQ RHQVVYEILA RTPYGSVETG QVGINRLLSE QVFTAAYPLH EGGFQPPAPP
     ASPESLGLRQ ILYVYWAKWS CWRRYQPLDH IREYFGEKIA LYFAWLGFYT GWLLPASFVG
     TVIFLFGFWL VATDVPAKEL CDSGNNFIMC PICNICSYWN YSSICVTYKA GLLFDNGGTV
     FLSVFMSLWA VTFLEYWKRT CSALSHRWDC SEFEATEERP RPEFTAMAPM TTRNPVTGAE
     EPYFPENKRF KRILTGCMAI IIMIAVVLMF LIGIILYRTI LSIIISKAEN SLLIFSAGRI
     ASITGSVLNL LVILMLSRVY ITLAQVLTSW EMHRTQTKYE DMFTLKVFIF QFVNFYSSPV
     YIAFFKGRFV GYPGNYNTLF GVRNEDCGAG GCLIELAQEM LVIMVGKQLI NNIQEFIVPK
     LKSWWQKRKM SPRLKEVNKE GVEEAHVKQQ EEVVSPWEAD YQLLVCEGLF SEYLEMVIQF
     GFITIFVAAC PLAPLFALFN NWVEMRLDAQ KFVTEYRRPV AERAQDIGIW FPILQFITHT
     AVLSNAFLIA FTSSFVPRLY YRYTRDNMLS GYINFTLATS PRNYSQQHQH TSCRYLGFRD
     ENGKYLPEFF HLLAIQLSFV IIFEHVVFLI GNLIDMMVPD IPEEVELKMK REHYMAKEAL
     AENQTFGKAM SPGDMNSTSS NLRWRGSRAQ QPPHSDSPPP NLKDIPEEAS PPDSC
//