ID A0A3Q3MVJ7_9TELE Unreviewed; 1150 AA.
AC A0A3Q3MVJ7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 12 member 7b {ECO:0000313|Ensembl:ENSMAMP00000026841.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000026841.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000026841.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q3MVJ7; -.
DR STRING; 205130.ENSMAMP00000026841; -.
DR Ensembl; ENSMAMT00000027533.2; ENSMAMP00000026841.1; ENSMAMG00000018052.2.
DR GeneTree; ENSGT00940000157657; -.
DR InParanoid; A0A3Q3MVJ7; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..328
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 440..722
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 736..851
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 853..993
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1031..1150
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 23..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..989
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1150 AA; 127538 MW; 951724EB307F5E25 CRC64;
MGDRFVVVRV DGGAEREHRH AWVPNRGTDT SPGNIEGEGD PVLEPQDSNT VVPILEYSRE
PNKYGDGVPK ENSPFINSTD NDKGNSYDGT NMALFEEEMD SNPMVSSLLN KVANYTNLTQ
GAQEHEDADD DDEGSKKKAV KSPQMGTFMG VYLPCLQNIL GVILFLRLTW IVGTAGILES
LVIVGLCCSC TMLTAISMSA IATNGVVPAG GSYYMISRSL GPEFGGAVGL CFYLGTTFAG
SMYILGTIEI LLTYIVPKAA IFIAERKEDE ADALLNNMRV YGTCCLAMMA VVVFVGVKYV
NKLALVFLAC VILSILAIYA GVIKTIFEPP DFPVCMLGNR TLQNQHFDKC LKTDFIENMT
VTTKLWRLFC DGPELNATCN DYFFNNNVTQ VQGIPGLTSG VISENMWSEY GPAGVLVENK
KLPSSGGSDP TQDLYMPYVV NDITTFFTLL VGIYFPSVTG IMAGSNRSGD LRDAQKSIPI
GTILAITTTS IIYISCVVLF GACIEGVLLR DKFGDSVKGN LVIGTLSWPS PWVIVIGSFF
SCCGAGLQSL TGAPRLLQAI ARDGIVPFLQ VFGHGKANGE PTWALLLTAG ICEIGILIAS
LDSVAPILSM FFLMCYLFVN LACAVQTLLR TPNWRPRFKY YHWTLSFLGM SLCLALMFIS
SWYYAIVAMA IAGCIYKYIE YRGAEKEWGD GIRGLSLNAA RYALIRLEEA PPHTKNWRPQ
LLVLLNLDSD HGVKHPRLLS FCTQLKAGKG LTIVGSVLEG TYLTKETEAK KTEQNIKSHM
SAERTKGFCH VVVSSNLRDG VSHLIQSAGL GGMKHNTVLM AWPGTWRQSN DPVSWRNFIE
TVRETTAAHQ ALLVAKNIDS FPTNQDRLGE GTIDVWWVVH DGGMLMLLPF LLRQHKVWRK
CKMRIFTVAQ MDDNSIQMKK DLQMFLYHLR LDAEVEVVEM HDSDISAFTY EKTLVMEQRS
QMLKQMQLSR TEREREIQSI TDESRSSIRR KNQGATQSSQ QPSSMEAAQE DEAQLLHDRN
SATQATVNDK SDTGPERVHM TWTKDKLFTE RNRNREANAN VAVRDLFNMK PEWESLNQTN
VRRMHTAVKL NEVVVNKSQG AHLVLLNMPG PPQNRGGDEN YMEFLEVLLE GLNRVLLVRG
GGREVITIYS
//
