ID   A0A3Q3MVU0_9TELE        Unreviewed;      1185 AA.
AC   A0A3Q3MVU0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Rap guanine nucleotide exchange factor (GEF) 1b {ECO:0000313|Ensembl:ENSMAMP00000026936.1};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000026936.1, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000026936.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q3MVU0; -.
DR   STRING; 205130.ENSMAMP00000026936; -.
DR   Ensembl; ENSMAMT00000027629.2; ENSMAMP00000026936.1; ENSMAMG00000018110.2.
DR   GeneTree; ENSGT00940000156235; -.
DR   InParanoid; A0A3Q3MVU0; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT   DOMAIN          796..918
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          948..1172
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          27..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          692..712
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          736..776
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..263
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..403
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..459
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..614
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        751..767
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1185 AA;  132171 MW;  28384EE2AF495263 CRC64;
     MSGKIESKQD SQRSHLSSFT MKLMDKFHSP KIKRTPSKKG KQLQAEPAAK STEKPANKKV
     SRLEEHEKEV VSALRYFKTI VDKMVVEKKV LEMLPGSASK VLEAILPLVQ VEARIQHSSA
     LSSCHNRVYQ SLANLIRWAD QVMLDGIDLE DKENVASVTS VIKAVLDGVK ELVKLTIEKQ
     EQPSATTPIK SAPPATTAES SVSSEMPSID REQEVSKKTS PAATPAEATS DMPDEDVAPP
     KPPLPEAKMA ELSPPPALPP KKRQSAPSPT RVAVVAPMSR GSSLPCSVHR QQQDYEQEIL
     QRRFSGGSHS YGGDSPRLSP CSSMGKLSKS DEQLSSMEQD SGQCSRNTSC ETLDNTENYD
     PDYDFLHQDL SSGENLPHIP VGGCLSPLPE SHSESSSPVP GQLPSHPRFS APPPQQQSEY
     WTPQPNQTNP SQSSRISAPP ALPQKKRRST QTSSFSDGSR VLYERYPSQY DNLSEEELHP
     TPPFPLFTPI SPMPQTNGSV FVTQYMASEN ADVPTSPPPL PEKKSRHILQ YMQFVEDYSE
     PQPSVFYQMP QSESIYEQRN KRFQEVYGFN DSFSSTDSVH EPLQPPALPP KQRQLASHSS
     SPSSSSSSSL SCHLQPSVAA MEEVGTGLGL SMSVSNSYLI GQASLTTPTS LDQVALTNAT
     ILDGSGGGTN GSLAGSMGSV AVCLPSESSL TDSLHTSASE SANDEGGEGE YVNLYSSSQA
     NGELPHSLRE AIVTDDALQD PTPQIPSTNS KEALDKERRQ KSAESAGSDE EDVDELSLID
     HKEIMNRITL KQENDDGPDV RAGSGDILLV HATETDRKDL VLYCEAFLTT YRTFITPEDL
     IKKLHYRYTR FCHSPDTFKK RVSKNTFFVL VRVVDELCLV ELTEDILKQL MDLVFTLVCN
     GELSLARVLR KNILDKVEQK KLLRYTNSLK PLAARGVSAR PGTLHDFRSH EIADQLTLLD
     AELFYKIEIP EVLLWAKEQN EEKSPNLTQF TEHFNNMSYW VRSLIIQQEK AQDREKLLLK
     FIKIMKHLRK LNNFNSYLAI LSALDSAPIR RLEWQKQTSE GLEEYCTLID SSSSFRAYRA
     ALAEVEPPCI PYLGLILQDL TFVHLGNPDL IDGKVNFSKR WQQFNILDSM RRFQQVHYEL
     KRNEDIVSFF NDFSDHLAEE ALWELSLKIK PRNITRRKTD REEKT
//