ID   A0A3Q3MZ91_9TELE        Unreviewed;       497 AA.
AC   A0A3Q3MZ91;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   Name=KPNA3 {ECO:0000313|Ensembl:ENSMAMP00000025424.2};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000025424.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000025424.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q3MZ91; -.
DR   Ensembl; ENSMAMT00000026078.2; ENSMAMP00000025424.2; ENSMAMG00000017029.2.
DR   GeneTree; ENSGT01050000244891; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR024931; Importin_alpha.
DR   PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR   PANTHER; PTHR23316:SF6; IMPORTIN SUBUNIT ALPHA-4; 1.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005673};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT   REPEAT          90..134
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          133..160
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          260..298
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   497 AA;  54752 MW;  55479593E58F78B1 CRC64;
     QQQHGTEVLH NNKRDEHLLK KRNVPQEESL EDSDVDSDFK GVINYAALHS SSLQNATSDN
     AVIQLSAVQA ARKLLSSDRN PPIDDLIKSG ILPILVKCLE RDDNPSLQFE AAWALTNIAS
     GTSAQTQAVV KSNAVPLFLR LLHSPHQNVC EQAVWALGNI IGDGPQCRDY VISLGVVKPL
     LSFINPSIPI TFLRNVTWVI VNLCRNKDPP PPMETVQEIL PALCVLIYHT DINILVDTVW
     ALSYLTDGGN EQIQMVIDSG VVPFLVPLLS HQEVKVQTAA LRAVGNIVTG TDEQTQVVLN
     CDVLSHFPNL LTHPKEKINK EAVWFLSNIT AGNQQQVQAV IDAGLIPMII HQLAKGDFGT
     QKEAAWAISN LTISGRKDQV EFLVEQNVIP PFCNLLSVKD SQVVQVVLDG LKNILIMAGD
     EASTIAEIIE ECGGLEKIEN LQQHENEDIY KLAFEIIDQY FSGDDIDEDP SLIPETTQGG
     TFNFDPASNM QAKEFNF
//