ID A0A3Q3N0K4_9TELE Unreviewed; 763 AA.
AC A0A3Q3N0K4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000033513.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000033513.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR AlphaFoldDB; A0A3Q3N0K4; -.
DR Ensembl; ENSMAMT00000034372.2; ENSMAMP00000033513.1; ENSMAMG00000022527.2.
DR GeneTree; ENSGT01050000244905; -.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16845; STAT1_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 6.10.250.3310; signal transducer and activator of transcription 1; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR038295; STAT1_C_sf.
DR InterPro; IPR022752; STAT1_TAZ2-bd_C.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF18; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA_BETA; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12162; STAT1_TAZ2bind; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 571..667
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 130..181
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 763 AA; 88265 MW; FF4281D1A86A463B CRC64;
MAQWCQLQML DSKYLEQVDQ LYDDSFPMDI RQYLSKWIES IDWDAVVFQD SLAIVRFHDL
LAQLDDQHSR FALENNFLLQ HNIRKIKRNL QDRFQDDPVH MAMIISRNLK EEQKILANAK
STEQEGEGMV SAMVVEKQKL DNKVKEMKDR VQFVDQNIKN LEDLQDEYDF KINTLKNREN
EMNGMTPKEL EREKLDIGRM GFDLKAKRQD VVLQLTDLLN VTQALVNDLI SEELPEWKQR
QQIACIGGPP NACVDQLQNW FTAVAESLQQ VRQHLKKLQE LEQKFTYDSD PFTQKKTLLE
NRALELLKNL LSNSLVVERQ PCMPTHPQRP LVLKTGVQFT VKLRFLVKLQ EFNYQLKVKA
LFDKDVTEKK GFRKFNILGT NTKVMNMEES NGSLAAEFRH LQLKEQKVAG NRTNEGPLIV
TEELHSLSFE SELQLNQSGL DIKLEAISLP VVVISNVCQL PSGWASILWY NMLTTEPKNL
KFFLSPPAAK WSQLSEVLSW QFSSVTKRGL NQEQLNMLAD KLLGAKAQRN PEGLIPWTKF
CKQSANEKSF PFWLWIEGIL DLIKRHLLSL WNDGSIMGFI SKEREKALLS DKCPGTFLLR
FSESSREGAI TFTWIEHDVH DKPVFHSVEP YTKKELGAVS LPDIIRTYKV MAAENIPENP
LRFLYPNIPK DKAFGKYYPK PSEPSEPMEV EDTEKSGYMK TELISVSEVH PSRLHDNMMP
MSPDDYKVLK HYVRDIEADA VTDTLIGFEH FDVQMTAGFS NQN
//
