ID A0A3Q3N278_9TELE Unreviewed; 1177 AA.
AC A0A3Q3N278;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000026384.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000026384.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q3N278; -.
DR STRING; 205130.ENSMAMP00000026384; -.
DR Ensembl; ENSMAMT00000027060.2; ENSMAMP00000026384.2; ENSMAMG00000017663.2.
DR GeneTree; ENSGT00940000166212; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF448; PROTEIN JAGGED-1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1177
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030081674"
FT TRANSMEM 1021..1045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 173..217
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 218..251
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 284..322
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 324..360
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 362..398
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 400..436
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 438..473
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 475..511
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 513..549
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 579..615
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 617..653
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 655..691
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 693..729
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 732..768
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 770..806
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 808..844
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1105..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 175..184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 188..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 208..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 241..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 312..321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 350..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 388..397
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 426..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 442..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 463..472
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 501..510
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 539..548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 605..614
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 643..652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 681..690
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 719..728
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 758..767
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 796..805
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 834..843
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1177 AA; 128932 MW; 6D0932EBA7ACD342 CRC64;
MILRRGSVLA ALLLCFLGSG QFELQILSMH NVNGELLSGV CCDDARSAPD RKCSRDECDT
FFKVCLKEYQ SRVSAAGPCS FGMGSTPVLG GNTFSFKSSV RNDKSRIVLP FSFAWPRSYT
LIVEALDFNN ETSGADGKLI EKAFHSGMIN PSLHWQKLTH NGPVAQFEYQ IRVSCDEHYY
GFGCNKFCRP RDEFFGHYTC DYNGNKTCLE GWSGPDCNTA ICRQGCSTEH GSCKEPGGCK
CLYGWQGQYC DKCIPHPGCV HGTCVEPWQC LCDTNWGGHL CDKDLNYCGT HQPCLNGGTC
INTGPDKYQC TCAEGYSGAN CERAEHACLS NPCSNGGSCS ETSQGYECQC ALGWSGPSCT
INIDDCSPNP CNHGGTCQDL VNGYKCHCPS QWTGKTCLID ANECESKPCV NANSCRNLIG
GYFCECVPGW AGQNCDININ DCKDQCQNGG TCKDLVNGYR CMCPPGFTGE HCERDIDECA
SSPCMNGGRC LDEVNGFRCL CLAGFSGNLC QLDIDYCSPN PCHNGAPCFN LATDYYCACP
EDYEGKNCSH LKDHCRTTTC KVIDSCTVAV ASNSTPGGER YISSNVCGPH GRCRSQAGGQ
FSCECQEGFR GTYCHENIND CESNPCRNGG TCIDKVSVYQ CICGDGWEGD HCEINIDDCS
TNPCHNGGTC RDLVTDFFCE CKNGWKGKTC HSRESQCDEA TCNNGGTCHD EGDTFQCKCS
PGWEGTTCNI AKNSSCLPNP CENGGTCVVT GESFKCVCKE GWEGPTCTQN TNDCSPHPCY
NSGTCVDGDN WYRCECAPGF AGPDCRININ ECQSSPCAFG STCVDEINGY RCLCPPDRAG
PHCQEVTRKS CSVNGHVMAD GTKWEEDCNT CHCSNGKVVC TKVCLNKLIL GAKGRGGCPS
NQICIPIREG HCFVKPCPDL GECWRSNPPP APTKCHPSSS YQDNSCANIT FTFNKEIMPR
GLTVEEVCKQ LRHLNVVKNF SLEHSVSITC DPSFSASNEI HVCIVSTSSH SQIVFFLPSD
YLVPLLSSIF IVIWVLMLVS ILLWCMRRRR KQSNHNGASA TGSEDNTTNN VREQLNQIKN
PIEKHVGLTV AIKDYENKNS LIAKIRTNHP EGDEDDKERH LQKGRFAKQP AYTLVERDEK
TPISNPNSTS KHPNWTNKQD NRDLETANSI NRMDYIV
//
