ID A0A3Q3N2G7_9LABR Unreviewed; 267 AA.
AC A0A3Q3N2G7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Dehydrogenase/reductase SDR family member 6 {ECO:0000256|ARBA:ARBA00039194};
DE EC=1.1.1.104 {ECO:0000256|ARBA:ARBA00038956};
DE EC=1.1.1.30 {ECO:0000256|ARBA:ARBA00038959};
DE AltName: Full=(R)-beta-hydroxybutyrate dehydrogenase {ECO:0000256|ARBA:ARBA00043083};
DE AltName: Full=3-hydroxybutyrate dehydrogenase type 2 {ECO:0000256|ARBA:ARBA00042309};
DE AltName: Full=4-oxo-L-proline reductase {ECO:0000256|ARBA:ARBA00043199};
DE AltName: Full=Oxidoreductase UCPA {ECO:0000256|ARBA:ARBA00042565};
DE AltName: Full=Short chain dehydrogenase/reductase family 15C member 1 {ECO:0000256|ARBA:ARBA00041727};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000028030.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000028030.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH;
CC Xref=Rhea:RHEA:20521, ChEBI:CHEBI:10983, ChEBI:CHEBI:13705,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.30;
CC Evidence={ECO:0000256|ARBA:ARBA00035857};
CC -!- PATHWAY: Amino-acid metabolism. {ECO:0000256|ARBA:ARBA00034698}.
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR AlphaFoldDB; A0A3Q3N2G7; -.
DR STRING; 56723.ENSLBEP00000028030; -.
DR Ensembl; ENSLBET00000029362.1; ENSLBEP00000028030.1; ENSLBEG00000021228.1.
DR GeneTree; ENSGT00940000156721; -.
DR InParanoid; A0A3Q3N2G7; -.
DR OrthoDB; 102925at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:Ensembl.
DR GO; GO:0042168; P:heme metabolic process; IEA:Ensembl.
DR GO; GO:0042541; P:hemoglobin biosynthetic process; IEA:Ensembl.
DR CDD; cd05368; DHRS6_like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43477:SF4; 3-HYDROXYBUTYRATE DEHYDROGENASE TYPE 2; 1.
DR PANTHER; PTHR43477; DIHYDROANTICAPSIN 7-DEHYDROGENASE; 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
SQ SEQUENCE 267 AA; 28855 MW; 76BF191ECE87A9DE CRC64;
MHAGGVHKYS STDFIICGER CTMGRLDGKV IVLSAAAQGI GRAAAIAFAK EGAQVTATDI
NGEKLKELDS VQGIKTKVVD VTKKDQVEAL AKEHEHVDVL FNVAGFVHHG SVLDCEEADW
DFTMNTNVRS MYLMCKAFLP KMLEKKSGNI INMASVASSI KGVVNRCVYS TSKAAVIGLT
KSIAADFIDK GIRCNCVCPG TVDTPSLRGR IQAQPDPEEA YKAFMARQKT GRMCTAEEVA
YLCVYLASDE SAYVTGTEQI IDGGWRL
//
