ID A0A3Q3N2Y2_9TELE Unreviewed; 1457 AA.
AC A0A3Q3N2Y2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000034328.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000034328.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
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DR Ensembl; ENSMAMT00000035202.2; ENSMAMP00000034328.2; ENSMAMG00000023065.2.
DR GeneTree; ENSGT00950000183021; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF07469; DUF1518; 2.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 2.
DR SMART; SM01151; DUF1518; 2.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR038181};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR038181}.
FT DOMAIN 27..84
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 120..184
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 74..104
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1274
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1457 AA; 157229 MW; 02A437DD5624C249 CRC64;
MSGVGENSSD PVRAESRKRK ECSAELLGPS SKRINEKRNR EHENKYIEEL AELIFANFSD
IDNFNVKPDK CAVLKETVKQ IRQIKEEEKA AAANEEEVQK ADVSSTGQSV IDKDALGPVM
LEALDGFFFV VNMEGNIVFV SENVTQYLRY NQEELMNTSV YSILHVGDHA EFIKNLLPKS
LVNGVPWSSE GPRRNSRTFN CRMLVNPHNT SQEEPHDHDS QQQKYETMQC FAVSEPKSIK
EEGDDLQSCL ICVARRVPIK ERPMLPTHES FTTRQDLQGK ITSLDTSLLR ASMKPGWEDL
VRRCIQRFHL QNDGEMSFAK RHQQEVLRHG QAFSPIYRFS LSDGTIVSAH TKSKLVRSAA
TNEPQLYMSL HILQREQTLS GMGQDMGPGN QATAMAPKPM NSSTPSMTPP IPGSLPGLGP
QGQDTTISSN SMPFSPPGPR EPAVIGGHIQ GYPGGPHPPQ QNSVLSPRHR GSPGGSGSPC
VAGGLQSPSS VGMCGGIVGS NSTSNTSYTS SSLSALQALS ECHSVGHGHG PPHAHTLGSP
DQKTGSPAGV TPGSGVNTHQ MSKIGAGCLT TGCTGDSFGP DTPVGQGQTQ GQTESNLAEP
KEEQEGPPEG HDAHNHPHEN KGHTKLLQLL TTNPEPLEMA LSPDVGGEGK IQTGTGVRCA
HTGVNTHATS LKEKHKILHQ LLQSSTSPVD LAKLTAEATG KELAQDQTPG GASTVSGAEI
ASKQDPMSPK KKDNALLRYL LDKDDTALKD KVSNLEPREM KVDGAKNPHV KAAKQDTGYD
RAEQSSELED ILNDLQNAQP QLFCGSRPVS LPSPMDKQNI IADILQMSET NPGMAAQPRA
VRPGQSCRVL PVRSVSLDMN VLPQQPSLQY PIRASSPYTI TPQQQQTVGS HSMMTNQANM
VNTGLMAAGV SRPAMQQQEG WAGSASSPGQ QGVMQGRTGP NSAPVRPNSQ PVPRQMLHSP
LMTNAQPEMD IAVGGHNFSH QQAPPNQTAP WPDSMLPIDQ TAFVSQNRYV GSADGPAVDE
GALMSQLYTV LKDFEGLEEI DRALGIPALV EQSQSLEPEQ FPQDTSILLG QKLPVYTQQF
SNLPSHIAQR GYPGTLMQEP GFHSMSGQMG PRPGYPINRM QARPGLRHTG VIPNQPNTLR
LQLQHRLQSQ QNRQPMMTQM SGVSNVNLPL RTSAPNQGTI NAQMLAQRQR ELLSNHLRQR
QQQQVQQQRS MAMRAPGLNL PTSMATGGMS NPRIPQTNPQ QLPYPPSYGT STGVALPPPP
TSPFSSPLSP SLPSLPANPQ LHLHANSSPS STSSCSSQMM MGNTNMMGGQ YGAVLSPQMQ
HSAFQFPNSG ISQQADGGFG GPSTPQSPLL SPHMVHTQSP MIQQGQGNTA FQGSPDMNGW
PQGTMGGNSM FSQQQTSPQF TQQNNGNMYN NSSISLNSVS MPSNMATSSM RSIGRMTGQI
SVTSMASPNM YCMMFKG
//
