ID   A0A3Q3N3U4_9TELE        Unreviewed;       709 AA.
AC   A0A3Q3N3U4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE            EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000031217.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000031217.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC       perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|ARBA:ARBA00009085}.
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DR   AlphaFoldDB; A0A3Q3N3U4; -.
DR   STRING; 205130.ENSMAMP00000031217; -.
DR   Ensembl; ENSMAMT00000032034.2; ENSMAMP00000031217.2; ENSMAMG00000021021.2.
DR   GeneTree; ENSGT00390000018123; -.
DR   InParanoid; A0A3Q3N3U4; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:1904888; P:cranial skeletal system development; IEA:Ensembl.
DR   Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR11830; 40S RIBOSOMAL PROTEIN S3A; 1.
DR   PANTHER; PTHR11830:SF17; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD; 1.
DR   Pfam; PF01302; CAP_GLY; 1.
DR   Pfam; PF00443; UCH; 1.
DR   SMART; SM01052; CAP_GLY; 1.
DR   SUPFAM; SSF74924; Cap-Gly domain; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50245; CAP_GLY_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          255..298
FT                   /note="CAP-Gly"
FT                   /evidence="ECO:0000259|PROSITE:PS50245"
FT   DOMAIN          352..697
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
SQ   SEQUENCE   709 AA;  79662 MW;  0E03FF872B2819F2 CRC64;
     MELKTVAEEK FFIVIRGKSR RGFSRGCIGR VEAETQQGDL MGLLYCGASS TGSPKCGGTV
     KKEDTFPLTR HQAQLLLFIF SLSKRLELLC NPQLFSAICE LSQDDLVVVK HKKGHLPGLV
     RNLMQIGRKE NKDDLHMLGF EVELMENDNL STKKPAPLPL FNAADIIQVI PSYPSLPPQW
     RDGQSVGLNR KAVTRINSMP SIGCRARQVR ENNIEHSAIQ SQSSSTSHVP LEVGSTVEVL
     SNSGIIMYGV VRWLGVPAGK TDEWAGIELD YEVNCCSDGT YENQRYFTCQ GNMALFVPVT
     KCSPDSRLFC SSPVRKTPNT EIPQVPSFEE SGENAPPIPE SEALSLLVGR MKGIQGHINS
     CYLDATLFSL FSSSVTLDNI CQKPADKDQP ITCTLRKIVN CLRRQGFVPA ESVMNLRKQL
     GCDTFQTEEK DPEEFITVLF EKVLCLEPLL KLRSRQETSQ GAYTFQIFLE KEQMVQMPTV
     QQLLDTSCLS GDLKFEDVPS CLIIQMPRFG NKYKMFSHII PSTELDITDL LYNSPRECFI
     CGNLAEYECL HCLPDHKLQP GRIKQYCATC NAQVHRHHSR QGHSPKTLEV PTDVASDAPV
     PRHMMELFAV LCIHTSHYVS FVKYGRDPRS WLFFDSMADR CGNDQIGYNI PEIQACPELG
     DFLSQPEEEL ARTNPSQAPE LVRRLLCDSY MFLYQNPVMA LSKPNHQEP
//