ID A0A3Q3N6K1_9TELE Unreviewed; 671 AA.
AC A0A3Q3N6K1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Leucine zipper putative tumor suppressor 2 homolog {ECO:0000256|HAMAP-Rule:MF_03026};
DE AltName: Full=Protein LAPSER1 {ECO:0000256|HAMAP-Rule:MF_03026};
GN Name=LZTS2 {ECO:0000256|HAMAP-Rule:MF_03026};
GN Synonyms=LAPSER1 {ECO:0000256|HAMAP-Rule:MF_03026};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000032112.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000032112.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of katanin-mediated microtubule severing
CC and release from the centrosome. Required for central spindle formation
CC and the completion of cytokinesis. Negative regulator of the Wnt
CC signaling pathway. Represses beta-catenin-mediated transcriptional
CC activation by promoting the nuclear exclusion of beta-catenin.
CC {ECO:0000256|HAMAP-Rule:MF_03026}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03026}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000256|HAMAP-Rule:MF_03026}.
CC -!- SIMILARITY: Belongs to the LZTS2 family. {ECO:0000256|HAMAP-
CC Rule:MF_03026}.
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DR AlphaFoldDB; A0A3Q3N6K1; -.
DR STRING; 205130.ENSMAMP00000032112; -.
DR Ensembl; ENSMAMT00000032947.2; ENSMAMP00000032112.2; ENSMAMG00000021604.2.
DR GeneTree; ENSGT00940000154078; -.
DR InParanoid; A0A3Q3N6K1; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-UniRule.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR GO; GO:0060026; P:convergent extension; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:UniProtKB-UniRule.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0051168; P:nuclear export; IEA:UniProtKB-UniRule.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0051255; P:spindle midzone assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR HAMAP; MF_03026; LZTS2; 1.
DR InterPro; IPR045329; LZTS.
DR InterPro; IPR028597; LZTS2.
DR PANTHER; PTHR19354; ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR19354:SF4; ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED; 1.
DR Pfam; PF06818; Fez1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW Rule:MF_03026};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW Rule:MF_03026}; Coiled coil {ECO:0000256|HAMAP-Rule:MF_03026};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03026};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212, ECO:0000256|HAMAP-
KW Rule:MF_03026};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|HAMAP-
KW Rule:MF_03026};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|HAMAP-Rule:MF_03026};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|HAMAP-
KW Rule:MF_03026}.
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 588..650
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03026"
FT COMPBIAS 175..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 74644 MW; DE5298C064512818 CRC64;
MALVQALPVT DHPNPGLDVH PGTAMGSVSS LISGRTYQER HCRAGSEFNA KPRRSTPATS
CFRLQDNTLR SGSSLEQLLV PRPGNSAGAY RTASPCSDPE DQRDNRTLNG NIGGPPPKLI
PVSGQLEKNI EKVLIRPTAF KPVVPKNRHS VQYLSPRPGG SSLSESQASL HLVLPLGGSN
SANSTNGNGG GSSSSSEGKR NSYSGSRNAR SSQSCSMSDS GRNSLSSLPT HSSTGYSLAP
SEGSSSRSGS GGQLEPTSGL GRNTSGGSGS HGHTNSDSGR SSSSKSTGSG SLSGRGQPLS
DSGSCGHSPP PVEGYEAVVR ELEEKLRERD LELQQLRENL DENEAAICQV YEEKQRRCER
EMEELRQSCA TKMKQASQKA QRAQQVLQLQ VFQLQQEKKK LQEDFSSLLQ DRETLERRCA
TIQREQTQLG PRLEETKWEV CQKSGEISLL KQQLKEIQSE LSQKAGDIVV LKAQLREARS
ELQASQVRSQ EAQTALRTRS LELEVCENEL QRRKSEAELL REKVGRLEEE SVRLRGGPSP
SMYRDGEETH LVWGGESDEA KAQRQNAETV FALRQQVDRL KAELMYERRT REEQLSRFED
ERRVWQEEKE KVICYQKQLQ QNYIQMYRRN RDLERVMREL SLELENRDME DYEVHSGSND
IHFEEITATE I
//
