ID   A0A3Q3N8P7_9TELE        Unreviewed;      1051 AA.
AC   A0A3Q3N8P7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Torsin-1A {ECO:0000256|ARBA:ARBA00013611};
DE   AltName: Full=Dystonia 1 protein {ECO:0000256|ARBA:ARBA00033320};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000028584.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000028584.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00001836};
CC   -!- SUBUNIT: Homohexamer. Interacts with TOR1B; the interaction may be
CC       specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and
CC       TOR1AIP2; the interactions induce ATPase activity. Interacts with
CC       KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR
CC       repeats); the interaction associates TOR1A with the kinesin oligomeric
CC       complex. Interacts with COPS4; the interaction associates TOR1A with
CC       the CSN complex. Interacts with SNAPIN; the interaction is direct and
CC       associates SNAPIN with the CSN complex. Interacts with STON2. Interacts
CC       (ATP-bound) with SYNE3 (via KASH domain); the interaction is required
CC       for SYNE3 nuclear envelope localization. Interacts with VIM; the
CC       interaction associates TOR1A with the cytoskeleton. Interacts with
CC       PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to
CC       the plasma membrane. {ECO:0000256|ARBA:ARBA00025909}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, growth cone
CC       {ECO:0000256|ARBA:ARBA00004624}. Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004156}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000256|ARBA:ARBA00006235}.
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DR   AlphaFoldDB; A0A3Q3N8P7; -.
DR   STRING; 205130.ENSMAMP00000028584; -.
DR   Ensembl; ENSMAMT00000029326.2; ENSMAMP00000028584.2; ENSMAMG00000019247.2.
DR   GeneTree; ENSGT00950000182888; -.
DR   InParanoid; A0A3Q3N8P7; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR049337; TOR1A_C.
DR   InterPro; IPR010448; Torsin.
DR   PANTHER; PTHR10760; TORSIN; 1.
DR   PANTHER; PTHR10760:SF15; TORSIN-1A; 1.
DR   Pfam; PF21376; TOR1A_C; 4.
DR   Pfam; PF06309; Torsin; 3.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT   DOMAIN          145..288
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          480..623
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          815..958
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   1051 AA;  119749 MW;  FE61F8255C5F4EEF CRC64;
     MKARGQKSDQ NKAHKLAKDL EYFPKFWEAS STRGCKTVEA RLEFYTMSTS DGNCSVTMST
     SNKYNALKQM NKESKSSVVV KSLDPINYEW QQIFNSHESC DSKWISFNAE GLRADVESKL
     IGQHIASSII LKAVEGFMSD TNPQKPLVLS LHGPSGTGKN FVSKLIAGNI YKEGMDSSFV
     HIFISTYHFP HQGHVDLYKT QLQQWIKDKI THCERSMFIF DEMDKMHPGL TDSIMPYLGY
     HNKLDGVSYR KAIFIFLSNA GGEIITETAL KFWKEGKDRE EIELKDLETL ISATAFNNNN
     SGFWHSSLID RHLVDFFVPF LPLQYGHVII CAMATMKARG QKPDQNKAHK LAKDLEYFPK
     FWEVFSARGC KTVEARLEFY MMSTSDGNCS VTMSTSNKYN ALKQMNKESK SSVVVKSVDP
     INYEWQQIFN SHESCDSKWI SFNAEGLRAD LESKLIGQHI ASSIILKAVE GFMSDTNPQK
     PLVLSLHGPS GTGKNFVSKL IAGNIYKEGM DSSFVHIFIS TYHFPHQGHV DLYKTQLQQW
     IKDKITHCEH SMFIFDEMDK CPPGLMDSIM PYLGYHNKLD GVSYRKAIFI FLSNAGGEII
     TETALKFWKE GKDREEIELK DLETLISATA FNNNNSGFWH SSLIDRNLVD FFVPFLPLQY
     GHVIICAMAT MKARGQKPDQ NKAHKLAKDL EYFPKFWEVF SARGCKTVEA RLEFYMMSTS
     DGNCSVTMST SNKYNALKQM NKESKSSVVV KSLDPINYEW QQIFNSHESC DSKWISFNAE
     GLRADVESKL IGQHIASSII LKAVEGFMSD DNPQKPLVLS LHGPSGTGKN FVSKLIAGNI
     YKKGMDSSFV KVFTSTFHFP HKENIDRYKT QLQQWIKDKI THCERSMFIF DEMDKMHPGL
     TDSIMPYLGY HNKLDGVSYR KAIFIFLSNA GGEIITETAL KFWKEGKDRE EIELKDLETL
     ISATAFNNNN SGFWHSSLID RHLVDFFVPF LPLEYRHVVI CAIAAMKARG QKPDQNKAIK
     LAEDLDFFPK FERAFSVRGC KTVEARLEFY T
//