ID   A0A3Q3N8V2_9TELE        Unreviewed;       952 AA.
AC   A0A3Q3N8V2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSMAMP00000032832.1};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000032832.1, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000032832.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   AlphaFoldDB; A0A3Q3N8V2; -.
DR   STRING; 205130.ENSMAMP00000032832; -.
DR   Ensembl; ENSMAMT00000033684.2; ENSMAMP00000032832.1; ENSMAMG00000022098.2.
DR   GeneTree; ENSGT00940000163999; -.
DR   InParanoid; A0A3Q3N8V2; -.
DR   OrthoDB; 1207361at2759; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00365; LRR_SD22; 7.
DR   SMART; SM00369; LRR_TYP; 12.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..952
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018676992"
FT   TRANSMEM        740..765
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          792..933
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   952 AA;  108690 MW;  E647D485C377530B CRC64;
     MPIKGSVCLY FVQEVLLVLL FLLLHLTPSL AYSLKNCTIT YSADVFVNCA DRKLVTVPDD
     IPRDATITEL SSNNLKQISR EDFRDMSKLR ILILNNNKIA HVDDGSFIHL GALKYLDMSS
     NQLTILTAKL FQGLSNLNLL DLSSNYVQFI HNSTFQFLPG LHTVKLGDNQ LQQITDIQPI
     LQVPHLQVLS LGCSLFSSFD TKDLPLNMSS GLKVLEISGN NLENFSISTP IFPHLETIDI
     SGCNQPLVLK WDIPDKTFLK NITRLIINNA EFPFRNVQKV LMSLDSLMHL TLDYSKLVNK
     RVLATVCKIP TLRILDLLNN QISNLSVQLV ACSQLSELVL SSNYMAEISK SSIQSMKRLR
     SLDASTNLLT KVPDDVRSLS SLEILDLSDN HISDLSCEDF INTTHLTELY LGLNHISRLD
     NCVFKNLNDL KILDVRENLL WTFGGAFKLG LHALESLHLG NNFILCYDMG GFQGLESLKY
     LDLRSDKVSS IKHKAFDGLD NVETLTVSIA TELDYNFREL HKLENLTIYF NIGSSFRSPP
     SNFYESFYHL KYLKFFTVIC KGNEFAFPFD LQPQIFEGMR HLEDFTAEGI YSSAPAPDTF
     RFNFRLRSLS INQADLSNLD PELFLPIPNL QVMDFFKCKI RSLDFLAQAD LPALRYLILS
     SNEISVINET VFQSLPALTY LDLDNNPFIC DCSNAGFIQW VKSNNRTQVV NAYQYTCSFP
     EAEHGQKLLD FDIGSCSMDF GFLCFISSTC LVVLTLVTSF VYHFLRWQLA YTFYLLLAFL
     YDSRKRKKGA PHQYDAFISY NVHDEPWVHR EMLPALEGEQ GWRLCLHHRD FQPGKPIIEN
     ITDAIYGSRK TICVISRRYL QSEWCSREIQ MASFRLFDEQ KDVLILLFLE DIPAWQMSPY
     HRMRKLVKKR TYLSWPQAGG HSGVFWENVR RALETGDAPM ENTNLLTGPA EP
//