ID A0A3Q3N8V2_9TELE Unreviewed; 952 AA.
AC A0A3Q3N8V2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSMAMP00000032832.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000032832.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000032832.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3Q3N8V2; -.
DR STRING; 205130.ENSMAMP00000032832; -.
DR Ensembl; ENSMAMT00000033684.2; ENSMAMP00000032832.1; ENSMAMG00000022098.2.
DR GeneTree; ENSGT00940000163999; -.
DR InParanoid; A0A3Q3N8V2; -.
DR OrthoDB; 1207361at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..952
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018676992"
FT TRANSMEM 740..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 792..933
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 952 AA; 108690 MW; E647D485C377530B CRC64;
MPIKGSVCLY FVQEVLLVLL FLLLHLTPSL AYSLKNCTIT YSADVFVNCA DRKLVTVPDD
IPRDATITEL SSNNLKQISR EDFRDMSKLR ILILNNNKIA HVDDGSFIHL GALKYLDMSS
NQLTILTAKL FQGLSNLNLL DLSSNYVQFI HNSTFQFLPG LHTVKLGDNQ LQQITDIQPI
LQVPHLQVLS LGCSLFSSFD TKDLPLNMSS GLKVLEISGN NLENFSISTP IFPHLETIDI
SGCNQPLVLK WDIPDKTFLK NITRLIINNA EFPFRNVQKV LMSLDSLMHL TLDYSKLVNK
RVLATVCKIP TLRILDLLNN QISNLSVQLV ACSQLSELVL SSNYMAEISK SSIQSMKRLR
SLDASTNLLT KVPDDVRSLS SLEILDLSDN HISDLSCEDF INTTHLTELY LGLNHISRLD
NCVFKNLNDL KILDVRENLL WTFGGAFKLG LHALESLHLG NNFILCYDMG GFQGLESLKY
LDLRSDKVSS IKHKAFDGLD NVETLTVSIA TELDYNFREL HKLENLTIYF NIGSSFRSPP
SNFYESFYHL KYLKFFTVIC KGNEFAFPFD LQPQIFEGMR HLEDFTAEGI YSSAPAPDTF
RFNFRLRSLS INQADLSNLD PELFLPIPNL QVMDFFKCKI RSLDFLAQAD LPALRYLILS
SNEISVINET VFQSLPALTY LDLDNNPFIC DCSNAGFIQW VKSNNRTQVV NAYQYTCSFP
EAEHGQKLLD FDIGSCSMDF GFLCFISSTC LVVLTLVTSF VYHFLRWQLA YTFYLLLAFL
YDSRKRKKGA PHQYDAFISY NVHDEPWVHR EMLPALEGEQ GWRLCLHHRD FQPGKPIIEN
ITDAIYGSRK TICVISRRYL QSEWCSREIQ MASFRLFDEQ KDVLILLFLE DIPAWQMSPY
HRMRKLVKKR TYLSWPQAGG HSGVFWENVR RALETGDAPM ENTNLLTGPA EP
//