ID A0A3Q3NB88_9LABR Unreviewed; 649 AA.
AC A0A3Q3NB88;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364117};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU364117};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000031340.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000031340.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU364117};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364117}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446, ECO:0000256|RuleBase:RU364117}.
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DR AlphaFoldDB; A0A3Q3NB88; -.
DR Ensembl; ENSLBET00000032765.1; ENSLBEP00000031340.1; ENSLBEG00000023652.1.
DR GeneTree; ENSGT00940000157013; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032392; P:DNA geometric change; IEA:UniProt.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd18015; DEXHc_RecQ1; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF72; ATP-DEPENDENT DNA HELICASE Q1; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364117};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU364117};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364117};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364117}; Nucleus {ECO:0000256|RuleBase:RU364117};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT DOMAIN 115..290
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 315..466
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 613..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 7..48
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 649 AA; 72436 MW; 974A8CE18931447C CRC64;
MDGVCRTNDV QAQLDSVESE LELVELQIAE LLQKQAELTD QKNSLLLKLE DACDAAQPSS
SSSSSSKSSG AQPVMSKQEL KCYDGTDFPW SKEAEKHLKG SFGLSKFRPL QLRAINLSLS
GKDLFLVMPT GRGKSLCYQL PAVCSEGFTL VVTPLLSLME DQIMYLKSIE VSAVILNANS
SKEHAKTVMA GMTDPKSPFK LLYVTPEKIA KSKLLMSRLE KSYKANLLSR IAVDEVHCCS
QWGHDFRPDY KLLGILKRQF PKVPLLGLTA TATSSVLKDC EKILCVQQPI TITASFNRTN
LYYEVRIKDS NNDASISDVA ALIKSRYKDQ SGIVYVFSQK DAESVASELQ NRDILAYPYH
GHMDPNDKSR VHRKWTANKI QVVVATVAFG MGIDKPDVRF VIHHTISKSI ENYYQESGRA
GRDDRPADCI VYYGFSDIFR ISNMVVMENV GQQKLLQMVD YCQNLDRCRR SLMAVHFDEV
WDDEGCNQMC DTCRDAKDFS TLDITQHARE VVQILELAES MDEKVTPLKL VEAWLGKGPA
KRRKMIQTTS LSRLQAEAVV VRMLLLGYLK EDFSFTPYTT YFYLKLGRKA PLLKSASHTV
SMKMRQTGAD SAAAAVKAAR GPVKAKEGKR SGQSAGDAPE SKKVKTDLL
//
