ID A0A3Q3NEC7_9TELE Unreviewed; 1616 AA.
AC A0A3Q3NEC7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Low-density lipoprotein receptor-related protein {ECO:0000256|PIRNR:PIRNR036314};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000030799.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000030799.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers
CC beta-catenin signaling through inducing aggregation of receptor-ligand
CC complexes into ribosome-sized signalosomes.
CC {ECO:0000256|PIRNR:PIRNR036314}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Forms phosphorylated oligomer
CC aggregates on Wnt-signaling. {ECO:0000256|PIRNR:PIRNR036314}.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|PIRNR:PIRNR036314}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR STRING; 205130.ENSMAMP00000030799; -.
DR Ensembl; ENSMAMT00000031603.2; ENSMAMP00000030799.1; ENSMAMG00000020748.2.
DR GeneTree; ENSGT00940000158990; -.
DR OrthoDB; 3107655at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0042813; F:Wnt receptor activity; IEA:InterPro.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR017049; LRP5/6.
DR PANTHER; PTHR46513:SF40; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 12.
DR PIRSF; PIRSF036314; LDL_recpt-rel_p5/6; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 15.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|PIRNR:PIRNR036314};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR036314};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR036314};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|PIRNR:PIRNR036314};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR036314};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR036314};
KW Wnt signaling pathway {ECO:0000256|PIRNR:PIRNR036314}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|PIRNR:PIRNR036314"
FT CHAIN 20..1616
FT /note="Low-density lipoprotein receptor-related protein"
FT /evidence="ECO:0000256|PIRNR:PIRNR036314"
FT /id="PRO_5018383532"
FT TRANSMEM 1375..1395
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR036314"
FT REPEAT 108..150
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 151..194
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 195..237
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 286..325
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 373..415
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 416..458
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 459..502
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 503..545
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 592..629
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 675..717
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 718..760
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 761..803
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 844..886
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 893..931
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 978..1021
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1027..1069
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1070..1114
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1115..1157
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1207..1251
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1458..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1271..1286
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1289..1301
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1296..1314
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1308..1323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1327..1339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1334..1352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1346..1361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1616 AA; 180853 MW; 369E1F5BF6062D37 CRC64;
MGVALRSLLL WSFCLLVRGV PLLLYANRRD LRLVDAAHEK ANATVVVGGL EDAAAVDYVY
SKGLIYWSDV SEEAIKRTVF NQSGASTVQT VVPGLASPDG LACDWLASKL YWTDSETNRI
EVAELDGSLR KVLFWQELDQ PRAIALDPER GYMYWTDWGE VPKIERAGMD GTNRSMIIDK
EIYWPNGLTL DYSQQKLYWA DAKHNFIHRS NLDGSSREVV VKGELPHPFA LTLYEDTLFW
TDWTTHSIHS CRKQTGGEQR VVHSDIFSPM DIHVFSPERQ HALSSPCVVK NGGCSHLCLL
SPVKPYYQCA CPTGVQLLED GKTCRDGATQ MLLLARRTDL RRISLDTPDF TDIILQVDDI
RHAIAIDYDP VEGYIYWTDD DVKAIRRSLP DGSDAQFVVT SQVNHPDGIA VDWIARNLYW
TDTGTDRIEV TRLNGTMRKI LISEDLDEPR AIVLDPVAGY MYWTDWGEVP KIERADLDGT
ERVVMVNTSL GWPNGLALDY DERKIYWGDA KTDKIEVMNM DGTERRVLVE DKLPHIFGFT
LLGDYIYWTD WQRRSIERVH KHTAEREFII DQLPDLMGLK ATYVHESFGT NPCAENNGGC
SHLCLYKPLG VQCGCPIGLE LIADMRTCIV PEAFLLFSRH TDIRRISLET NNNNVAIPLT
GVKEASALDF DITDNRIYWT DITLKTISRA FMNGSALEHV VEFGLDYPEG MAVDWLGKNL
YWADTGTNRI EVAKLDGQHR QVLVWKDLDS PRALALDPAE GYMYWTEWGG KPKIDRAAMD
GTGRITLVAD VGRANGLTID YAERRLYWTD LDTTLIESSN MLGQDREVIA DDLPHPFGLT
QYQDYIYWTD WSQRSIERAN KTSGQNRTVI QGHLDYVMDI LVFHSSRQGG WNACASTNGH
CSHLCLAVPV SSFVCGCPAH FSLNYDNKTC SAPTSFLLFS QKTAINRMVI DEQQSPDIIL
PIHSLRNVRA IDYDPLDKQL YWIDSKQNVI RRAQEDGNQS MTVVSSSVSG PTQGLQMYDL
SIDIYSRFIY WTSEVTNVIN VTRTDGSRVG VVLRGEHDKP RAIVVNPERG YMYFTNLLER
SPKIERAALD GTEREVLFFS GLGKPVALAI DNEVGKLFWV DSDLRRIESS DLSGANRIVI
ADSNILQPVG LTVFGNHLYW IDKQQQMIER IDKTTREGRT KVQARIAYLS DIHAVHELDM
REYSKHPCTW DNGGCSHICI VKGDGTTRCS CPVHLVLLQD ELSCGEPPTC SPEQFSCTSG
EVDCIPKAWR CDGFPECDDS SDEVNCPVCS KSEFQCDSRQ CIDLSLRCNG EINCQDRSDE
NKCDVPCPPD QFTCSNGQCI GKHKKCDNNM DCTDNSDEIG CYPTEEPPPP PNNTIGSIVG
VVMALFVVGA VYFVCQRVLC PQMKDDGETV TTDFVVHGPS SVPLGYVPHP SSLSSSLPGM
SRGKSVIGSL SIMGGSSGPP YDRAHVTGAS SSSSSSTKGT YFPPILNPPP SPATVRSQYT
MEFGYSSNSP STHRSYSYRP YTYRHFAPPT TPCSTDVCDS DYTPGRRAPL KSSTAAKGYT
SDLNYDSEPF PPPPTPRSQY LSAEENCESC PPSPYTERSY SHHLYPPPPS PCTDSS
//
