ID A0A3Q3NEX1_9TELE Unreviewed; 702 AA.
AC A0A3Q3NEX1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Golgi associated, gamma adaptin ear containing, ARF binding protein 3b {ECO:0000313|Ensembl:ENSMAMP00000035137.2};
GN Name=GGA3 {ECO:0000313|Ensembl:ENSMAMP00000035137.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000035137.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000035137.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR AlphaFoldDB; A0A3Q3NEX1; -.
DR Ensembl; ENSMAMT00000036041.2; ENSMAMP00000035137.2; ENSMAMG00000023587.2.
DR GeneTree; ENSGT00940000157333; -.
DR InParanoid; A0A3Q3NEX1; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14240; GAT_GGA3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR044111; GAT_GGA3.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF3; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 16..146
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 171..298
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 573..694
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 151..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..238
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 316..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 76591 MW; 701A2E0451C440A3 CRC64;
MAYQEGESLE SWLNKATHPA NRQEDWEYII GFCDQVNKEL EGPQIAVTLL VHKIHSPQEW
EALQALTVLE ACMKNCGRRF HNEVGKYRFL NELIKVVSPK YMGDSTPEKV KMKIVEMLYS
WTVAFPSEVK ISEAYQTLRR QGLVTRDPEL PLDRTLIPSP PTRPKHPVFD NEDMGKLLAE
LLRSKNPEDL QEANRLIKNM VKEDEARVHK VTKRINTLEE VNINVKLLTE MLSQYNKDSS
TESDKEIIKE LYERCDKLRR AAFKMATETE DNDTSLGDIL QASDDLSRVI NSYKNIVEGQ
PINNDSEEPR SIAAHSESET TDTLIDLTSI DAPSTPQPII PLSQCSDPAS ASLTASPIPV
LPPPPKRLAG SHGSQSSSPS RTTPSKASTA LSLLDDELLS LGLNDPPTSL SNQSKPKLNE
VSSQWSSLQA PAAGMDMFGS ITHSGPVLAP ADPAATIHTL QNLQELAMMG FSDHKSLSSQ
VSARGSSFGI TPAAVPAFIP GQGSLSSVSV LQGTMPGSPA MSHAKAHSLG SAPGSPLFRS
LSPCHPPLQD SPARTIDISL SNVHVPLEAI RPSKVLPVTA YDKDGVRVLL NFASDCPPGR
PDVLVMVVSM LNTAPLPVHN VVLQAAVPKS MKVKLQPPSG TELAAFNPVL PPASITQIML
LANPAKEKVR LRYKLSFTLG DRLCNEVGEV DQFPPPEAWG FL
//
