ID A0A3Q3NGL6_9TELE Unreviewed; 1412 AA.
AC A0A3Q3NGL6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000035231.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000035231.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR STRING; 205130.ENSMAMP00000035231; -.
DR Ensembl; ENSMAMT00000036137.2; ENSMAMP00000035231.2; ENSMAMG00000023642.2.
DR GeneTree; ENSGT00940000157151; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14632; R-PTPc-U-1; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 718..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..156
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 158..249
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 256..351
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 354..455
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 461..561
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 879..1110
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1030..1101
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1142..1405
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1321..1396
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1412 AA; 159364 MW; 1954588022D489F0 CRC64;
DKRKNLCDFT QGEEDDFDWL LFRTYSSPYA SSDLLHGSYM LVNSSQHAVG HRAQLLLQTL
SENDTHCVQF SYFLYSRDGH SPGALRAYVR VNGGPLGSPV WNMSGTHGKQ WHQVELAVST
FWPNEYQVLI EATVSSERRG YIAIDDIMVL NYPCYKAPHF SRLGDEEVNA GQNATFQCVA
AGRASEAERF LLERHNGDIL TAASVKHLSH RRFVVSFQLD NVQRSDQDLY RCVTQSSRGS
GVSNFAELVV KVPPSPIAPP QLLRAGSTYL IIQLNTNSIL GDGPIIRKEI EYRASQSPWS
EVHGVNMVTY KLWHLDPDTE YHISVLLTRP GEGGTGPPGP PLVSRTKCAE PMRALRDLTA
TDIQSRQLSL QWENLAFNLT RCHTYSVSLC YRYTTAGGGG GHNTTVRECL AVEHNASRFT
LRDLPPYHSI HVRLSLSNPE GKKEGREVTF QTEEDIPGGI APESLTFTPL DDMIFLKWEE
PIEPNGLITQ YEISYQSIES SDPGINVPGP RRTVSKLKNE TYHMFSNLHP GTTYLISVRA
RTAKGFGQTA LTEITTNISA PMFDYGDMPS PLSETESTIT VLLRPAQGRG APVSTYQVVV
EEETGKKVKR ELGLQECFPL PMSHGEAQAR GTPHYYTAEL PPSSLTEASP FTVGDNHTYN
GYWNSPLDPR KSYLVFFQAM SNFRGESRIN CIRIARKAAC KDHRKALEVS QHSEEMGLIL
GVCAGGLVVL ILLLGAVIII IKKGRDYYSY YPKPVNMNKT PITYRQEKSH MGSMERSFTD
QSTLQEDERM ALSFMDAHTC GTRSDARSSV NEASSLLGGS PRHQCGRKGS PYHTGQLHPA
VRVADLLQHI NQMKTAEGYG FKQEYESFFD GWDCTKKKDK TKGRQDTLLG YDRHRVKLHP
LLGDPNSDYI NANYIDGYHR SNHFIATQGP KQETLYDFWR MVWQENCFSI VMITKLVEVG
RVKCCKYWPD DSEMYGDIKI TLLKTETLAE YTVRTFALER RGYSTKHEVR QFHFTSWPEH
GVPYHATGLL AFIRRVKAST PPDAGPVVVH CSVGAGRTGC YIVLDVMLDM AECEGVVDIY
NCVKTLCSRR INMIQTEEQY IFIHDAILEA CLCGETAILV NEFAVTYKEM LRVDSQSNSS
QLREEFQTLN SVTPHLDVEE CSIALLPRNR EKNRSMDVLP PDRALAFLVT TEGESNNYIN
AALADSFHRQ AAFIVTPHPL PGTTADFWRL VFDYGCTAVV MLNQLNQSNS AWPCVQYWPE
PGLQQYGPME VEFLSMSADE DVVTRLFRVK NVTRLQEGQL VVCQFQFLRW SAYRDVPDSK
KAFLNLLAQV HKWQRECGEG RTVVHCLNGG GRSGTFCACN ILLEMIQYQN MVDIFYAVKT
LRNCKPNMVE SLDQYRFCYD LVLEYLDCFE GR
//
