ID A0A3Q3NJ36_9TELE Unreviewed; 901 AA.
AC A0A3Q3NJ36;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Neuropilin {ECO:0000256|PIRNR:PIRNR036960};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000032989.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000032989.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the neuropilin family.
CC {ECO:0000256|ARBA:ARBA00006078, ECO:0000256|PIRNR:PIRNR036960}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; A0A3Q3NJ36; -.
DR Ensembl; ENSMAMT00000033844.2; ENSMAMP00000032989.2; ENSMAMG00000022194.2.
DR GeneTree; ENSGT00940000155270; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0005021; F:vascular endothelial growth factor receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00057; FA58C; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR014648; Neuropilin.
DR InterPro; IPR022579; Neuropilin_C.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46806:SF2; NEUROPILIN-2; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF11980; DUF3481; 1.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR Pfam; PF00629; MAM; 1.
DR PIRSF; PIRSF036960; Neuropilin; 1.
DR PRINTS; PR00020; MAMDOMAIN.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00231; FA58C; 2.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01285; FA58C_1; 2.
DR PROSITE; PS01286; FA58C_2; 2.
DR PROSITE; PS50022; FA58C_3; 2.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRNR:PIRNR036960};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR036960};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|PIRNR:PIRNR036960};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR036960-2};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR036960};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR036960-1};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW ECO:0000256|PIRNR:PIRNR036960}; Receptor {ECO:0000256|PIRNR:PIRNR036960};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 835..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..133
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 140..258
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 268..418
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 425..585
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 623..785
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT BINDING 188
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-1"
FT BINDING 202
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-1"
FT BINDING 243
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-1"
FT DISULFID 19..46
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-2,
FT ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 74..96
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-2"
FT DISULFID 140..166
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-2"
FT DISULFID 199..221
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-2"
FT DISULFID 268..418
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-2"
FT DISULFID 425..585
FT /evidence="ECO:0000256|PIRSR:PIRSR036960-2"
SQ SEQUENCE 901 AA; 100356 MW; CEA82E8A1E9B381B CRC64;
HTHTHTHTHT PLLSWRTQCG GVLDASEAGY ITSPGYPMEY PPHQNCHWII TAPEPSQRIV
LNFNPHFEIE RLDCKYDFIE IRDGTSDTAD VLGRHCSNIA PAPIISSGPS LQIRFVSDYA
HQGAGFSLRY EIFKTGSEFC FRNFTSSSGM IESPGFPDKY PHNLECSYMI IAPPRMEITL
TFLTFDLEND PLLVGEGDCK YDWLDVWDGL PQVAPLIGRY CGTKIPPEIQ SSSGLLSLSF
HTDMAVAKDG FSARYNMTHK EVADSFHCSM ALGMESGKIS EDQISASTTF YDSRWLPRQA
RLNNNDNAWT PSEDSNKEYI QVDLHFLKVL TGIATQGAIS KETQKSYFVT TFKLEVSTNG
EDWMVYRHGK NHKTFHANTD PAEVVLNRVP QPVLARFVRI RPQTWKNGIA LRFELYGCQI
TDAPCSDLQG LLSGLLPDAQ ISASSSRDMV WSPGTARLVA SRSGWFPAPA QPLAGEEWLQ
VDLGVPKTVR GVITQGARGG DAGSGATTDN RAFVRKYKIA HSLNGKEWNF IMDSKTSLPK
IFEGNTHYDT PELRHFEETV AQYIRLYPER WSPAGIGMRV EILGCDLPET TTPADTVTPT
LPADIETTTV PITSPATTPP SDSVCDFDHG LCGWTHDSNA PLYWSLHSNG ESPHQSDFTL
LLLLSGYFLY MDASLKTEQQ RARLMSPVVA AETGPLCLLF SYQLSGEAQG HLKVLLREAH
NEETIIWTLK DDQGLVWKEG RTILPRSPKE FQVVMEGFFV HGTRGHIWID NIHMSSSTPL
KECTQPYAAF SPENSGTFHF VLQLPEWNTA SPSSEPPVTR VSEKDNSWLY TLDPILVTII
VMSALGVLLG AVCAGLLLYC TCSYSGLSSR SSTTLENYNF ELYDGLKHKV KLNQQRCCTE
A
//
