ID A0A3Q3NK23_9TELE Unreviewed; 917 AA.
AC A0A3Q3NK23;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) {ECO:0000313|Ensembl:ENSMAMP00000033514.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000033514.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000033514.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q3NK23; -.
DR STRING; 205130.ENSMAMP00000033514; -.
DR Ensembl; ENSMAMT00000034373.2; ENSMAMP00000033514.1; ENSMAMG00000022530.2.
DR GeneTree; ENSGT00940000164992; -.
DR OrthoDB; 1059550at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF21; NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 45..236
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 512..533
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 551..583
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 584..605
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 621..653
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 689..721
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 352..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..742
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 99488 MW; 01117202FC28269B CRC64;
MAGALRMTEA QFMNVYDNDL QLNLMPYDYI PPVDIKTEPH IPETAHGPYI QIIEEPKQRG
FRFRYECEGP SHGGLPGASS EKNRRTYPTV KINNYMGHAR VEVQLVTHSD PPQVHAHSLV
GRHCTDKGTC TLDVGPNDLT ASFSNLGILH VTKKGVVEIL YKRLSEEKKR QKGPHSTLAE
AELSACLKEA KELGKVMDLN IVRLKFTAYL QDSNGGFTRA LKPVISNPIY DSKSPNASNL
KISRMDKTCG SVLGGDEIFL LCDKVQKDDI EIRFYEEDDE GGWEAFGDFS PTDVHKQYAI
VFKTPPYHST EIERPVTVFL QLKRKKAGDS SNPKQFTYIP QVQDKEEVLR KKQKPLPHYE
PWRGGGAGGR GGGAGSFGGG AGAGAGAGGG FQFTQQMNGA GGGTGGFYSG SFTNFGGGGT
QMSDSTSQTG VTEQQTSGQV ERQTGQTGQT GQTGPTGGPL QQQLFQIAAA LHSRASQSAK
QAAAALLQYC STGDARVLLA IQRHLCGVQD VNGDTPLHLA IIHQQTDVIQ QLIHTVLSSQ
QLNILNTANH LQQTPLHLAV ITRQVKVVEV LLRAGADPSL LDKDGRSPLH LAALAGDSVT
LRPLLAHLGK RHTLVNSPDF HGLHPLHLAM RRDGERCLRL LVDGGANVNA PEQKSGYTAL
HLAVRENLFK VACTLITELK ADVNACTFGG NTPLHLAASL GSPTLCSMLV AAGADKNMEN
DEPLFFSSSS DEEQDGDEPV REEAAEQEGA SSQEVNPLKR RAGGHTPLDL AKCQKVRNLL
NSRHSPKSSR HSSKKMKASG SEEVEASGLD EETLSRLVEV LSGKDWKRLA EKLGMMTLTH
VYQDSPTPCH HLLQHYKLGG GPVEGLIEAL QSLGLTEGVR LLRNRDMQDD KHSTDATVDS
GFGSQPMEEE EPPVTNQ
//
