ID   A0A3Q3NNL7_9TELE        Unreviewed;       625 AA.
AC   A0A3Q3NNL7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Growth factor receptor-bound protein 10-like {ECO:0000313|Ensembl:ENSMAMP00000035784.2};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000035784.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000035784.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GRB7/10/14 family.
CC       {ECO:0000256|ARBA:ARBA00006708}.
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DR   AlphaFoldDB; A0A3Q3NNL7; -.
DR   STRING; 205130.ENSMAMP00000035784; -.
DR   Ensembl; ENSMAMT00000036702.2; ENSMAMP00000035784.2; ENSMAMG00000024040.2.
DR   GeneTree; ENSGT00940000155909; -.
DR   InParanoid; A0A3Q3NNL7; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01259; PH_APBB1IP; 1.
DR   CDD; cd10415; SH2_Grb10; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR015042; BPS-dom.
DR   InterPro; IPR039664; GRB/APBB1IP.
DR   InterPro; IPR035037; Grb10_SH2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039665; PH_APBB1IP.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR   PANTHER; PTHR11243:SF4; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 10; 1.
DR   Pfam; PF08947; BPS; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          195..279
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          321..430
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          524..620
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          17..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..112
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   625 AA;  70978 MW;  BCC6635A7550E64B CRC64;
     MAVAGCPDYF LHHPNYQQDN IDRSSNHRQT DLIGSPSHQE DDVDLEALVN DMNSSLESLY
     STCSGQQTES TPLLHNGQTS SSHQHHHHHH LHHHHPHHHH TQQNHPRQGH HSHVLSHVSP
     ELTSPSSLSG ELPQTGLRRS QPMHILAVRR LQEEEQQLRT SSLPAIPNPF PELCSPASSP
     VLSPGSLPPG EASTGKYIVK IFSEDGIGKV VEIPADMTAR DLCQLLVYKS HCVDDNSWAL
     VEHHPLLGLE RCLEDHELVV QVQASMTSDS RFLFRKNYAK YEFFRSPLTF FPEHMVAWCQ
     ETNHTIPPSQ LLKNFLATSS CPEIQGYLYV KDFGRKSWKK VYMFLRRSGI YCSTKGTSKE
     PRHLQLLADL EDSNIFTVIT GKKQHGAPTD YGFCIKPSKG RGELKELRML CAEDEQGRTC
     WMTAFRLFKY GIVLYQNYKI PQQRKTLLSH FSAPVRSVSE NSLVAMDFSG RIGRVIDNPV
     EAQSAAMEEG HAWRKRSHRM NILGSHSPLH HSSLSSVIHI AQLWFHGRIT REESHRIIHQ
     QGQVDGLFLL RVSQSNPKAF VLTLCHHQKI KHFQILPCEE DGQVFFSLDD GATKFTDLIQ
     LVEFYQLNRG VLPCKLKHPC TVVAL
//