ID A0A3Q3RN09_9TELE Unreviewed; 740 AA.
AC A0A3Q3RN09;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Exostoses (multiple) 1c {ECO:0000313|Ensembl:ENSMAMP00000005230.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000005230.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000005230.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR AlphaFoldDB; A0A3Q3RN09; -.
DR STRING; 205130.ENSMAMP00000005230; -.
DR Ensembl; ENSMAMT00000005365.2; ENSMAMP00000005230.1; ENSMAMG00000003497.2.
DR GeneTree; ENSGT00940000163960; -.
DR InParanoid; A0A3Q3RN09; -.
DR OrthoDB; 1220028at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..390
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 475..723
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 740 AA; 86273 MW; 494C955C86C96ABD CRC64;
MQARKKYVLL GLCACCWLVL FYWGGGVQLR LLRLLTRQRG EVVRPWPNWT DRAFLPRYAH
LDELQTDPGM AESPRQRRQA WSAIYKDSRC RMETCFDFSR CRRRGREGFR VYIYPSEKND
RVSESYRKIL MSIAESRYYT SDPREACLFV LGIDTLDRDQ LSGQFVPSVD ERIRGYPLWN
DGRNHLIFNL YSGTWPNYTE DLGFNIGQAM LAKASLNTEH FRPGFDVSIP LFSKDHPQKG
GERGWLVRNT IPPRRKYLLM FKGKRYLTGI GSDTRNALHH IHNGKDIVLL TTCRHGKDWE
KHKDARCDHD NLEYERFDYQ ELLHNSTFCL VPRGRRLGSF RFLESLQAAC IPVLLSNGWE
LPFSDVIQWN QAVIEGDERL LLQVPSTVRA VGNERILALR QRTQMLWEAY FSSVDKIVLT
TLEIIKDRVF SHISRNKYMW NSHPGGLLVL PEYSTHLAHF PFYYLGLGVS PGQEFTAVIH
AVSPLVSQSQ PIMKLLQVVS KSKYCSQIII LWNSEKPPPS RSKWPPMPVP LTVTDGRRKT
TSRFLPHVAI ETEAVLSLDE DTVLLTSEVN FAFLVWRSFP ERIVGYPPRS HFWDPLKRAW
GYTSKWTNDY SIVLTGAAFY HRYYHYLFSH YLPQSLRTLV DRTSNCEDIL MNFLVSAVTH
LPPIKVAQRK QYKELPSPQG TKSVPWANPE HFNQRQECVN TFANWFGYMP LVHSQFRLDP
VLFKDQVSVL RKKYKDLERA
//
