ID A0A3Q3RNA1_9TELE Unreviewed; 738 AA.
AC A0A3Q3RNA1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000005400.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000005400.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR AlphaFoldDB; A0A3Q3RNA1; -.
DR Ensembl; ENSMAMT00000005543.2; ENSMAMP00000005400.2; ENSMAMG00000003596.2.
DR GeneTree; ENSGT01080000257420; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16856; STAT6_CCD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF66; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 559..642
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 738 AA; 84892 MW; 3B698EEB4CCD21DA CRC64;
MAQWLHMSQL IPCLPDDTVN NLYPPPAFPI EVRHFLADWI ESQRWDDFVL EKVEMESQAR
ALLEQTISML QTMAQQNSNV VDRMKLMAIS RNMTRFQQQP LQFGVMVRDI LRKERVLLST
PPPPMSNPQQ YQQYPNRESS FLNLQDVDHL VLKVLQLQEV RKQKHQLQED LNWERQNFEG
LRCPTQPNGL DPSSSEIQKR KNQIQDMEFN VKVLFTKSFE LLKECVDCLD QCQTRLISRL
KTWRWEQHKA TIGHPFDDNL NPLQTWCEQL VGVNGKLRQE LMLIGEPVPE LQERLGKLLQ
VLIQSSLVVE KQPPQVIKTQ SKFSTTVRYL LGEKVAPGKP VMLKAQIINE IQARNLAVVP
ADNVGELINN SAILEHNTAT KSTCATFRNM SIKKIKRADR KGSESVTEEK FALLFSAEIT
ITGCDTPYRI QMISLPVVVI VHGSQDNNAL ATIIWDCAFS EPDRMPFVVP ERVPWRMMYS
TLNSKFTSEV QTQHGLDHYN QHFLAQKIFD KPDFAEDYSN MMVSWAQFNK EVLPGRPFTF
WQWFEGVMEL TKKHLKTYWS EGLIFGFIGK QHLHLILKDR PNGTFLLRFS DSEIGGITIA
YVSASENGGQ KIQNIQPFSK RDLEIRSLGD RIRDISHITH LYPEFPKDEV FKKFYSGNAV
CGLKGACVSL VIKATVPAEC FRHHFPQPFS PQESITPDNP CPTDMDFNPT TPVVYSEHIS
PGNNIDMELE SILQTLEP
//
