ID A0A3Q3RNM0_9TELE Unreviewed; 1980 AA.
AC A0A3Q3RNM0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Myosin XVIIIAb {ECO:0000313|Ensembl:ENSMAMP00000005625.2};
GN Name=MYO18A {ECO:0000313|Ensembl:ENSMAMP00000005625.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000005625.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000005625.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 205130.ENSMAMP00000005625; -.
DR Ensembl; ENSMAMT00000005782.2; ENSMAMP00000005625.2; ENSMAMG00000003726.2.
DR GeneTree; ENSGT00940000155768; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01386; MYSc_Myo18; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF13; UNCONVENTIONAL MYOSIN-XVIIIA; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 227..318
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 418..1173
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1283..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1839..1862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1504..1662
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1289..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 511..518
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1980 AA; 226463 MW; 0C9306CFE2C7C87B CRC64;
MFNLMKKDKE REGSRKEKKD KKDRMSAAEL RSLEEMSMRR GFFNLKREAK RESKNKLEIS
SPIPIKVVSN NDLTLNDLEL DGLSNRSSMV LDDQLSTASS MDDLKGEGAV GQDGHRSSVR
DRVAHFGSLA KQNSSQVGQM MKRFSFSQRS KEESPSEGST ASGQNSAVPS PQVESKVFSM
FCKHSLKQQP ETAATHEVCI PKVVDKTFAA QLQLPDVIAP NAPETRELEL QRRNTGDFGF
SLRRTTMLDR SPDGGVYRRV VHFAEPGAGT KDLALGLVPG DRLVEINGEN VENKSRDEIV
EMIRQSGDTV RLKVQPILEL SELSRCWLRN TEGLRREARH VSSLSWEWTE EQIAAEQVWY
GSEKVWLVHK DGFSLGELEL LMVNTQPEGK VNIKLEHDGT KLNVDEDDVE KANPPSHDQS
EDLASLLYLN ESSVMHCLRQ RYGGNLIHTY AGPNMVVINP LSTPSMYSEK VMHMFKGCRR
EDSAPHIYSV AQSAYRNLLT TRQDQSIVLL GRSGSGKTTN CQHLVQYLVS IAGSTGKIFS
AEKWQAVYTI LESFGNSSTA MNTNASHFSH VVSLDFDQAG QVASASIQTM LLEKLRVSRR
PEAELTFNVF YYLMAGADSS LRTELHFNHL SENSAFWILP QSKPEDKQRA MQQFTKLQAA
MKVLGISGEE QKALWLILGA IYHLGAAGAT KVGRRQFAHH EWAQKAAYLL GCTLEELSSA
VFKHQAKGLQ HSTSFRGGHD EAGQGSKVTA LECLEAMASG LYSEVFTLVI TLINRALKSS
QHSLCSLLIV DTPGFQNPRL AQQQRGATFE ELCHNYTQER LQTLFHERNF VQELERYKEE
NIELALDDIE SSTSLSVAAI DQASTQVRTL ARTDEARGLL WLMEEEAGQP GGSEETMLER
LFSYYGSAQG ENKGASLLLR GEKPHLFHLG HSHGTDWVEY NVQGWLSHAK HNPAAQNAVT
LLQDSQKKNI SGLFMGRTSG TTVLSGSIAG LAGSSQLALR RATSMRKTFT TGMAAVKKKS
LCIQVKLQVD ALIDMLRRSR VHFVHCLVPK AEAMGGVGEP RVMHGESPDS GLMTLDVSLL
RAQLRGSKLL DALRIYRQGY PDHMVFSEFR RRFDVLAPHL TKKHGRCYII TDEKKAVMEL
LESLELEKSS YHMGLSRVFF RAGTLSRLEE QRDIQTRRNI SLFQAACRGY LARQAFKKRK
IQDLAIRCIQ KNIKKNRGVK DWPWWRLFTT VRPLIEVQLT EEQIRGKDEE IQHLKLKLEK
VEKERNELRV NNDHLESRIT ELSSELADER NTGESASQLL ETETSERLHL EKDMKDLQDK
YDSMKKQMES MEMEVMEARL IRASELNGEL DDDDTGGEWR LKYERAIREV EFTKKRLQQE
IDDKLEVEQQ NKRQLERRIS DLQADNEESQ RNLQQLKKKT QRLTAELQDT KLHLEGQQNR
NHDLEKKQRK FDSELSAVQE EVQRERSLRE KLAKEKDLLT GETFNLHHQL EDKDLEVCAV
KLKLDQLEAE LQDLNSQESK DEASLAKVRK HLRDMEAKVK DQEEELDEQA GTIQMLEQAK
LRLEMEMERL RQTHSKEIES KDDEVEEIRQ SSSKKLKQME VQLEEEYSEK QKVLKEKREL
ESKFLSVRSG DIETEKRLRK DLKRTKALLA DAQIMLDHIK NNAPSKREIA QLKNQLEESE
FTCAAAVKAR KSMEAEIEDL HVQMEDISKT KQMLEEQLCR LQREKNDLQS KMEEDQEDLS
ELMKKHKAAV AQSAQNLAHI SDLQAQLEEA LKEKQEVQEK LQVLQSKLEF QEQSMVEKSL
VSRQDAKIRE LETKLEFEKT QVKRMESLVA RLKETVEKLT EERDQRSSSE NREKEQNKRL
QRQIRDIKEE MGELAKKEAE ASRKKHELEM DIESLEAANQ SLQADLKLAF KRIGDLQAAI
EDEREEFKLI FFFFITVNDA EFYGLLVKMW IEENDIPVFP LGLISLQFAH YFWLPHCSLY
//
