ID A0A3Q3RSB3_9TELE Unreviewed; 834 AA.
AC A0A3Q3RSB3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000008600.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000008600.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC Pro nor hydroxyproline.; EC=3.4.14.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001257};
CC -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC {ECO:0000256|ARBA:ARBA00010036}.
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DR AlphaFoldDB; A0A3Q3RSB3; -.
DR STRING; 205130.ENSMAMP00000008600; -.
DR Ensembl; ENSMAMT00000008824.2; ENSMAMP00000008600.2; ENSMAMG00000005830.2.
DR GeneTree; ENSGT00940000158174; -.
DR OrthoDB; 170111at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR045785; Dpp_8/9_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF19520; Dpp_8_9_N; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT DOMAIN 8..134
FT /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19520"
FT DOMAIN 174..553
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 634..834
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 834 AA; 95154 MW; F1073788802E4500 CRC64;
MTAVDGLADS TEVVEMEDVP CQFFVEKHSW EGLRDIIHCS RKYSGMIANK APHDFQFVQK
KDENGPHSHR LYYLGMPYGS RENSLLYSEI PKKIRKEALL VLSWKQMLDH FQATPHQGAY
SREEELLRER KRLGAFGITS YDYHPQTGMF LFQASNSLFY CQDGGNNGFI QSAPVKPVDI
KTQCSGTRMD PKICPGDPDF IAFINNNDLW IANIKTGEER KLTYCHKGMD NVKEDPKSAG
VATFVIQEEF DRFTGYWWSP SAVEDPSGGK TVYLLYEEVD ETEVEIIHVP SPALEERKAD
AYRYPRTGSK NPQATLKLAE IKTDHQGRIV STQDKELVIP FTSLFPGTEY IARAGWTSDG
KYGWAVLLDR SQRKLQLVLL PPALFIPVTD DPALRQESLE AVPSDTQPYI IYEETTDVWI
NVNDIFYPFI QTTEDEFTFI WVNESKTGFS HLYKITSLLQ PGCYHWTEDF KCVIKEEVPL
TSGEWEVLAR HGSKIWVNEA AKLVYFQGTR DTPLEHHLYV VSYDSPGDVV RLTKPGFSHS
CSVSQFTALV IYFCMHQFFW HLTNTFQTSS GCPGDYSPPE IFDFPGKSGF QLYGMVYKPH
NLQPGRKHPT VLFVYGGPQV QLVNNSFKGM KYLRLNTLAS LGYAVVVIDG RGSCQRGLEF
EGALKNKMGQ VEIEDQVEGL QYVAEKFNFV DLSRVAIHGW SYGGFLSLMG LIQRPNIFKL
AIAGAPVTVW MAYDTGYTER YMDVPENNQQ GYEEGSVALH VDKLPSEPNR LLILHGFLDE
NVHFFHTNFL VSQIIRAGKP YQLQVYPNER HSIRCPESGE HYEIMLLHFL QQYL
//
