ID A0A3Q3S1W6_9TELE Unreviewed; 1892 AA.
AC A0A3Q3S1W6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LRRK1 {ECO:0000313|Ensembl:ENSMAMP00000015745.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000015745.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000015745.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR Ensembl; ENSMAMT00000016174.2; ENSMAMP00000015745.2; ENSMAMG00000010626.2.
DR GeneTree; ENSGT00940000160363; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08477; Roc; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 535..716
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT DOMAIN 1132..1413
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1755..1779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1892 AA; 211997 MW; 2D4A37EC7644F533 CRC64;
MRPCGENSTQ KGPGVCYLLK EARITVPQEP SNSNPAILAA YYGHTNIVKE LLDSIPGSRD
LLNWMLATSC QQGHLDVVRL LIHGYDADAK DFAIHSNEFA VISGLPLYAA AQTGNVEIAC
FLLQNGAAFS SYTLMDHPAF SKQLLRLKLE ETSDTEGKEV FLCSVCGLQL PWLELDWFMD
ISSRITHLDL SSNSLSVLPS VMPWGLVHLQ TLDLSNNLLK ELPSAHSSQE VICSSLQQVN
LSMNQLTSLP PGLLHLIHIN RLSAAKNQLT VLFDIPTTTN WIGLRKLEEL DVSYNCLTCL
PVSVMHCLKS LSLLNVCRNK LSTFPDPWAC PLKQCKASSN VIESLPNTIS IFWKTQLEEV
DFSDNSLKEL PSYIFELEAL VSLRLCGNHI VTLPATSKWK CSQLRTLDLS RNQLGRTEDG
PKSRRLAFLT TWNRRDPDPV CPIEFPMILR DSMEVLYLND NQLECVPQSV CGLHNLTELY
VSNNPGIREL PAELGQLSNL WQLDTEGLNI TNVPQDVRKE GPASVLAFLR AHLRKAEPCK
LLKMLVIGPP RQGKTALLEV LQTGRTSPFT PAECSVSTST WDLDKPNGGK NSDSVVFNVW
DVGGQASMST VNQCFFTDKA LYVVIWNLAL GEEAVANLQT WLLNIEARAP NSAVVVVGTH
LDLIDTKFRT ERLATLRAYI LALCRSPSGA RATDCIQTLE GLDRLKKLIY HVAVSMKDSS
SSACGGKLLG RLIPRSYLTL QEAVKAEKQS RDAEGDVQYL TDAQLDHIIE QNPESDIRDY
EDLQSAISFL IETGTLLHFP DTSHGLCNIY FLCPVWLSEC LERIMHLKSS RSVARNGVIR
TEDLRMLLIG TGFTQQTEEQ YFQFLAKFEI ALPVAKNSYL LPHLLPTKPA MDIHGFRQQT
SNTLQRLFKM SFVPAGFWER FIARMLISLT ELDLQSFEPK RNTRNHSSRN SVIYSFAGTQ
QRNRCSTFRV RRSQTIYWKE GLLVTFDGGY LSIESSDVNW KKKKSGGIKI ICQSEMRDFS
AMAFITDHVN SLIEQWFPAL TATESDGSLL IEQYAPCPLC ASLQHGGDDE GEAGIYYFNM
EDCVLAAVEK EHIICPQHPD QPVPLQELVP ELFMTDFPAR LFLEKEELEY SVEENNVLGQ
GGSGTIIYRA RYRDQPVAIK CFHFKKCRQR TITSDTGRHL QSEDACRSFS EFRQEASMLH
SLQHPCIVSL VGISIHPLCF ALQLAPLGSL NAVLEEKRKG SKYMPLGHML TFRVAYQIAA
GLGYLHRKNI IFCDLKSDNI LLWSLEVHDP VNIKLSDYGI SRQSFHEGAL GVEGTPGYQA
PEIRPGIVYD EKVDMFSYGM VLYELLSGQR PALGQHQLQI AKKLSKGVRP VLGSPEEVQF
HCLHTLLTEC WDTKPEKRPV AMQCMKQMQD PSFACLRYIL SCDSHSQLFM SQLQGHSAVF
WKDDKDDRNY TVVNVEKGQV EVKRMSCPGS RISCQMKMCN TLWMATEEQE VFIYSLKDMC
PLSHPQKQFS CPAVITCLFP VPAREQVSSL FAGMFDGLVA VYTLVEDLPL EGETYLCSHT
LNKTVFGMKD TDPRQRPYPV RSMALVSGGS QLWFSNGPGV LVIDCLNLQA VRRLDPYSAP
SSIVSMATSF SLWGEEAVWT LDDHSNTLLL YHAASYDLCA KYCCGDCNPL RDVFTVQRPA
GLTTVTPTDL KTMDHEEKLE WTNGEVTLIY SEEAGTQIIQ HQDSLTDYCS ISSNCSLEQQ
GSDCSSTAGR SSFASSVPLS ADQDETERDQ DQQASTNPES YLGAAEAVIP TPPHLQAFTV
LPVNGTLWIP RRGGDIMVIE MQSNDDELKG RVIAVLKEAA LVAKDTVVCG FRKENTEWCL
CVWRGWGSHE LEVFYQCYEE LGRLETSMRK RR
//
