ID A0A3Q3S7G8_9TELE Unreviewed; 1056 AA.
AC A0A3Q3S7G8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Breast cancer anti-estrogen resistance protein 3-like {ECO:0000313|Ensembl:ENSMAMP00000018910.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000018910.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000018910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q3S7G8; -.
DR STRING; 205130.ENSMAMP00000018910; -.
DR Ensembl; ENSMAMT00000019404.2; ENSMAMP00000018910.1; ENSMAMG00000012752.2.
DR GeneTree; ENSGT00940000154130; -.
DR InParanoid; A0A3Q3S7G8; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd09487; SAM_superfamily; 1.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 1..64
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 267..366
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 782..1022
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 89..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1056 AA; 117644 MW; 31B92848511F8BAC CRC64;
MKHQSISRWL NQLGLPQYCA ALEQEYDGVE DLLHLTEHDL LELGVHNHLH RLHLLTSLCL
LQERERRREL RMMTEGRFAS LPRSLHAHHT LGGGTTLPGV PSTSVGVSSN SSCSSRRLQS
SLTSSMDLLS SRTGLPGQDA GLSELPAAAY QPVSIHGTLP RRKRGGANLN HGKYTWDPRA
NHTQPLVCAN TSQVPGHVHQ PMISPVVQNI IDDFHGYREP ATGLDATVDY VKFSRDQFIL
DCPSEKLRRE LEEELKMNCE DPRSHAWYHG AIPRQVAENL VQRDGDFLIR DSLSSPGCYV
LTCQWRNAAQ HFKINKKVVM LNEAYSRVEY WLEREGFDNV PALIRYYVGN RKPVSQVVGA
IIFQPINRGL PLRCLEEKYG IPSSHREAGS MAQERRSQKR LSLNITNGHA HDNTHSVHDN
THSQDNGMGR GSQLRLKDRC GSQPASLNQV PERRRPLKAH QSESFLPIGS KPQPQQTPDL
LHPSPNPKSP VFRTGSEPAL SPSVPRRSAE PLTDQTIRGS DSQLCPKPPP KPSKMLQARL
PRSPCLQPLV PPSSSSSNTG SSSTSHRLTA PPPESTGVET PASPWSSGAT TVPPVPPVKP
LKFPQQLLPA DPHSSSSSVV TPPELDQYLD SEAVAGQTEW LQLSPARQRP SSLLGKEETN
LPDCITDNGL ELQLPLCSYV ERLGKEEDTG ERRGLDRSSY HHAIAALENT SEEEEDDGGR
EEEDGQKDKW REKESSGFHR PVIETESTFR PAEFGSRLLP PENKPLEMVV LKRAKELLLK
HNHHSIARHL LMADCQVARI LGVTPELKGQ MGVSSGLELV TLPHGCQLRL DLMERHHTMA
IGVAVDILGC TGSVEERAST LNRIILVALE LKDTVGDLFA FTALMKALDL PQISRLEETW
TTLRRNYTQT AISYEKTLKP FYKSLYEGTA SCPPVVCVPL LLPLLTLMER PSITPEGPEL
WETSDQGCDI MLRHLEAARD VARNTQTYTN NAQKILQGFQ CDNDLLEVFK TDFHLRLLWG
SRGASVNQSD RYSKFNLILT ALSRKLEPTP KTQTLI
//
