ID   A0A3Q3S891_9TELE        Unreviewed;       704 AA.
AC   A0A3Q3S891;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000019395.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000019395.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
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DR   AlphaFoldDB; A0A3Q3S891; -.
DR   Ensembl; ENSMAMT00000019895.2; ENSMAMP00000019395.2; ENSMAMG00000008994.2.
DR   GeneTree; ENSGT00950000183011; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF1; AMP DEAMINASE 1; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640}.
SQ   SEQUENCE   704 AA;  81951 MW;  4D55689920F7CD86 CRC64;
     MRAFAEKVFA SETKDENVRD EISMFDVAED CPILHHEMAH HLHTDDDQTA PPLLHREHAL
     DADRPIYLEV PDYQRVAIIG DYAAGVTMDD FELSCKGLYR ALTIREKYMR LAFQRFPRTA
     SQFLREIEEE SFKPEDQLQP VFTPPPKKGE DPFDTKDLPE NLGYVARMKD GVIYVYNDAA
     AADKHQPKDL PCPNYDTFID DMNFLIALIA QGPTKTYTHR RLKFIMSKFN VHEMLNEMEE
     MKELKKNPHR DFYNCRKVDT HIHAAACMNQ KHLLRFIKKS YRVDADRVVQ ILKDREITLK
     ELFESLNLHP YDLTVDSLDV HAGRQTFQRF DKFNAKYNPV GASELRDLYL KTENHINGEY
     FATIIKEVAS DLEDAKYQYA EPRLSIYGSN TNEWNKLSSW FVKHRVFSPN LKWMIQVPRI
     YDIFRGRNFV PHFGKMLENI FLPVFQATID PQSNPELSIF LKHVTGFDSV DDESKHSGHM
     FSSKSPKPQK WDMNKNPSYT YYIYYMYANI AVLNQLRRQR GMNTFLFRPH CGEAGAITHL
     LAAFMTADNI SHGLNLKKSP VLQYLYFLSQ IPIAMSPLSN NSLFLEYAKN PLLEFHKKGL
     MVSLSTDDPM QFHYTKEPLM EEYAIAAQVF KLSTCDMCEI SRNSVLQSGM SHEEKICYLG
     EDYLKEGPES NDIRKTNVAQ IRMAYRYETL CYELNLVKEG LKIV
//