ID A0A3Q3SKF2_9TELE Unreviewed; 1019 AA.
AC A0A3Q3SKF2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000026240.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000026240.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR AlphaFoldDB; A0A3Q3SKF2; -.
DR STRING; 205130.ENSMAMP00000026240; -.
DR Ensembl; ENSMAMT00000026913.2; ENSMAMP00000026240.2; ENSMAMG00000017589.2.
DR GeneTree; ENSGT00550000074919; -.
DR InParanoid; A0A3Q3SKF2; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 66..97
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 127..168
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 170..201
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 766..964
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 408..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 111576 MW; C3472EFF6FA0FBA5 CRC64;
MKLLKPSWVS HNGKPIFSVD IHPDGTKFAT GGQGEDSGKV MIWNMAPVLR EEDEKNENIP
KMLCQMDNHL ACVNCVRWSN NGLYLASGGD DKLVMVWRRA AFIGPSTVFG SSSKLANVEQ
WRCVTILRNH TGDVMDVAWS PHDIWLASCS VDNTIVIWNA RKFPEMVTCL RGHTGLVKGL
TWDPVGKYIA SQADDHSLKV WRTVDWQMEA NITKPFSECG GTTHVLRLSW SPDGQYLVSA
HAMNNSGPTA QIVERDGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS PKPSCPYCCC
AVGSKDRSLS VWLTSLKRPL VVIHDLFDKS IMDISWTLTG LGMLVCSMDG TVAYLDFSLD
ELGDPLNEEE KNSIHQNIYG KSLAITSTEA QLSTTIIENP EMLKYQQERQ NSAQTNTGPG
SAGHESSAPK LNSVMNGESL EDIRKNLLKK QVETRTADGR RRITPLCIAQ LDTGDFSPAL
FNSVPILPSG SSMSNQLTSQ LSSDSSPGQA SSLGLRPNHD PMLTSPPPSG MPKVLEDKDG
VKSSLLLTSA SKIEPMKALD SRFTERSKAT PGVTAAISST AGMTPLDSRP KDGVSALKDV
KAKEETSSDS EDKMAAINKN LPFSKRKPEL PMDGGEVVEK RKKGRPRKDK MPAPITQTFS
QITPPAEREP SKVAAPPAPT AVLKLPTPST QKAFSLQVSM EPSVFLEVEN EVSVVAGSKL
SQLRCSRDGR DWNTLLPSSV VSAAGSSDVI AVACEDRMLS VFSSCGRRLL PAIQLATPVS
ALHCSAHFVM VLTAGATLSV WDVQKQKALV KNESLLTILS AAETTVSQSL LTQQGVPVVG
LSNGKSYCFS SSLQTWTLIA DRGDSLVQCA DFRSCLSTQD ALVSSGPLAV MQGRNLNAGR
LAARLSSTPH HLQQSMTLAF LENQLVSALT LQSAQEYRYW LLIYARFLVN EGSEYRLREL
CKELLGPVHR SAATSWEPTT LGLRKRELLM EVLPVIGENL RFQRLFTEYQ DQLDLLRNK
//
