ID A0A3Q3SUX7_9TELE Unreviewed; 2029 AA.
AC A0A3Q3SUX7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000031020.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000031020.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 205130.ENSMAMP00000031020; -.
DR Ensembl; ENSMAMT00000031828.2; ENSMAMP00000031020.2; ENSMAMG00000020888.2.
DR GeneTree; ENSGT00940000163423; -.
DR InParanoid; A0A3Q3SUX7; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR GO; GO:0006110; P:regulation of glycolytic process; IEA:Ensembl.
DR GO; GO:1904059; P:regulation of locomotor rhythm; IEA:Ensembl.
DR GO; GO:0002082; P:regulation of oxidative phosphorylation; IEA:Ensembl.
DR GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR GO; GO:0099536; P:synaptic signaling; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 206..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 237..258
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 416..443
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 771..789
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 801..824
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 836..860
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 881..909
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 971..994
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1236..1254
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1275..1294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1306..1326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1352..1378
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1474..1498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1557..1575
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1587..1605
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1617..1637
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1674..1702
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1778..1801
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 146..449
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 570..720
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 770..1000
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1008..1229
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1234..1507
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1556..1811
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 28..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1980..2029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1980..2003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2004..2029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2029 AA; 229608 MW; DF0CE0822B3D5FE9 CRC64;
MAQLLVPPGP DSFRPFIPES LAAIERRIAE EEARRPRAER RSDSDDENGP KPNSDLEAGK
SLPFIYGDIP SALVSSPLED LDPYYSNQKT FIVLNRGKAI FRFNATPALY ILNPFNPLRR
VAIRVLVHSY PFRVCYGHSL IRIKVMLIMF TILTNCAFMT LSNPPEWAKN VEYTFTGIYT
FESLIKILAR GFCVGKFTFL RDPWNWLDFS VILMAYITEF VNLGNVSALR TFRVLRALKT
ISVIPGLKTI VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRQK CVRLPLAING
SNSSNITGDD LLSLEMNTSF VQNATENTFN WTEYISDENN YYYLPGRRDA LLCGNGSGAG
LCPEGFFCVK AGRNPDYGYT SFDTFSWAFL SLFRLMTQDF WENLYQQTLR AAGKPYMIFF
VLVIFLGSFY LINLILAVVA MAYDEQNQAT IEEAQRKEEE FQAMLEQLKR QQEEAQVAAA
AAMESGEYSG RGGPTSESSS GTSKLSSKSA KERRNRRKKR KQREEEEEKG GRDKFRKSES
EDSIKRSSFR FSIDANRLSY EKRCSSPNQS LLSIRGSLFS PRRNSRASLF SFRGRARDMG
SENDFADDEH STFEESESRR GSLFLPRRFE RRCSAVSQTS LGAPRIMLPA NGKMHCAVDC
NGVVSLVGGT SVTTSPVGLL LPEGTTTDTE LKKRRSGFHQ PSMDYLDEPG GRPRAMSVAS
ILTNTMEELE ESRQKCPPCW YRFANTCLIW DCCPAWLKIK EVVNMVVMDP FVDLAITICI
VLNTLFMAME HYPMTKEFDT VLSVGNLVFT GIFTAEMCFK IIALDPYYYF QEGWNIFDGI
IVSLSLMELG LANVEGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA
IIVFIFAVVG MQLFGKSYKE CVCKISQSCE LPRWHMHDFF HSFLIVFRVL CGEWIETMWD
CMEVAGQTMC LIVFMMVMVI GNLVVLNLFL ALLLSSFSAD NLAATDDDSE MNNLQIAVGR
IQRGIAFVKG MLQQFLQSIC FGGGGKGSGL AEESKPLDEL HSNGKGNCIS NHTSVEITKD
PSGVYMTEGN GRPGGGLIVG DTTGKYPLEE CDYMSFIHNP SLTVTVPIAV GESDFENLNT
EDFSSDSSDI EGSKEKLDAE PQPLSSSEGS TVDIRPPGDG VDSVELEPEE SLDPEACFTE
GCVRRFQCCQ INEEGGKYKS WWTLRKTCFV IVEHNWFESF IIFMILLSSG ALAFEDIYIE
QRRTIKTVLE YADKVFTYVF ILEMVLKWVA YGFVKYFTNA WCWLDFLIVD VSLVSLVANA
LGYSELSAIK SLRTLRALRP LRALSRFEGM RVVVNALLGA IPSIMNVLLV CLIFWLIFSI
MGVNLFAGKY YYCINSTTDE VFPIDIVNNK SDCLNLANDS ARWKNVKINF DNVGAGYLAL
LQVATFKGWM DIMYAAVDSR NVEDQPNYEV NLYMYLYFVI FIIFGSFFTL NLFIGVIIDN
FNQQKKKMSC QDIFMTEEQK KYYNAMKKLG SKKPQKPIPR PTNAFQGCMF DCITKQAFDI
VIMILICLNM VTMMVETDDQ TAEMGNILYW INLVFIVLFT GECVLKLISL RHYYFTIGWN
IFDFVVVILS IVGMFLSEVI EKYFVSPTLF RVIRLARIGR ILRLIKGAKG IRTLLFALMM
SLPALFNIGL LLFLVMFIYA IFGMSNFAYV KREAGIDDMF NFETFGNSMI CLFQITTSAG
WDGLLAPILN KREPDCDSQM EHPGNTYKGN CGNPSVGIFF FVSYIIICFL IVVNMYIAVI
LENFSVATEE SAEPLSEDDF EMFYEVWERF DPDATQFMEY SKLSDFADAL DPPLRMPKPN
MIQLISMDLP MVSGERIHCL DILFAFTKRV LGEGGEMDVL RGQMEERFMA SNPSKVSYEP
ITTTLRRKQE EMSAIVIQRA FRRYMIQVAM KKASALYKEK LKEGIRDPDK DVMVISKFNE
NSTSDKTDMT PSTASPPSYN SVTKSDKDKY EKENREKENK GKDLKDRKK
//
