ID A0A3Q3VKD3_MOLML Unreviewed; 4425 AA.
AC A0A3Q3VKD3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000001496.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000001496.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 94237.ENSMMOP00000001496; -.
DR Ensembl; ENSMMOT00000001525.1; ENSMMOP00000001496.1; ENSMMOG00000001215.1.
DR OMA; ICEHMAY; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF12; DYNEIN AXONEMAL HEAVY CHAIN 11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620}.
FT DOMAIN 1811..1947
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2416..2561
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2755..2917
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3011..3041
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3228..3311
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4425 AA; 507974 MW; EC8B5F9C4EDDF4D6 CRC64;
MADEQTAPCF AEDVTVKFVG GKVCELLRLH RQTWQRSCAA EEFQTLLKGF FERQPAIFFW
SSKKGCLVAS NEVLFLRNPF LACLRDFWGE FILFFHSLNK VCTPLLSNHK NRQMWPNLMS
EDIVQHVERM CSRTSVVQGQ VSGKTVLPIP IATDWIENSY SALKMYNTYD RALAHAIETH
VINWTNLIQK ILKEDSSDQI LTPGCYPGPS AELRFWASRN SNIKHIYQQL QSPIVQKMTE
MLELMDSSYH PTINIVIGSV FDALQEAQDI NLHLQPLHAQ LLKLEKEGFP QFERYIPALF
HTLFLIWTNC QSYQRPAHIV VLLQELCNLL IEQASTYLHA DLLLREDMDE NLQMVRTVIK
VFRCFRHSYQ TQRERLANHV KHAPWDFPSA MIFARFKKFL NRMLQLEDFF EIFLDFQRME
KLEFGGLKGK LYSEHAAQMY MEFSNHCQAL QHSDSSPLDL NSQDFENDYK DFKVKIVDFE
CRLASLLSLA FQDCSGLESV FKLITIVGPF LERQQIQEIF SPSFLLLQQH FKQELETCRH
LLKSQLNQVE TGLSKNMAQT SGALKWAKML RERIQTSWEK IKLLFEMSEY RMYTEMLNLL
DQYEENIYSE WCNGLEQSCL TNLNHPLLSR DVSSGLISVN LNQKLTEVLK DVKYIQTLGQ
IKIHAAAMTV FEKRFIFTKY VNSLQLLVQW YNQLKQTVLE VELPLVRAEL ESIDLQLTRA
ESELTWQDLD CWSFISTTKD LVHNLVCRVT RAKENCEAIQ SMMKGWSKQA MFCRKDNKKG
SLIQLEDRED RVNKKYGSMK KDGDLIHKLV QENMALFHAE PASDAWYSYL EYLDEMVVEG
LFSYISCSLQ FFADNMESWS NQTPLFEAQL VLSNSEMVFV PSLEQDAGDG LYELIEGLIG
DIFKTSINVS RVATHLSMES YQDVMDDMLD LLDLRQEIME RVENVLEKAQ NYQRKFDCYA
HLWQDDRAEF LRHFLLYGRI LPAEDMEAYG ADTVPESPPS IANFKEQIDY YEDLYAEICK
LEDFGVFNGW FRVDVKFFKV SLLNTLKKWS WLFKEHLLTH VTNSLSELQK FVQATFEGLG
QSVANESHTG LVDVMSHLLA VRDRQAVTDK MFEPLRDTVI LLEQYGVTIP DQVYTQLEEL
PEKWNEAKKL ALKVRHEVAP MQNAEVMILR RQCMAFEVKQ IKFREMFRAM VPFSYNAVHP
YISLEKAEKA IRDMEKEVAE LQVSTNLFDV TIPDFRDIKL CRREIVVLKE LWDIVVFSSV
ENWTITKWRQ INVDQMDAEL RSFAKDIWKL DKEARVWDVY SGLDLYVKNL LTSLRAVSQL
QNMAIRERHW VQLMKTTQVR MEFSVTDSTT LEDLLALKLH MLEDEVRNIV DKAIKEMAIE
KVVTQISQTW KSMELSYEEH YQTSVQLLKS DQKLIETLED HQVQLQGIFQ SKHVDHFLFQ
VVELQKQLTV ADSVLMTWME VQKTWAYLES IFKGCDDICQ QLPADAHRFQ AIDVEFQELM
LDSVKTKNVI EATNKPHLFE KLEDLQKRLA LCEKALAEYL ETKRLEFPRF YFISSADLLD
IIAKGSRPRE VAVHLSKLFD NVSDLEFAKN EQGDNPKHAV GMYSKEREYV SFLSQCRCHG
PVEAWLTCLE ECMRESVRGH LSEAVSLYED RPREQWILDF PAQVALTGSQ IWWSNDMELV
FKRLDEGFES ALKDYNKKQI SQLNLLIGML LGELSSGDRQ KIMTICTIDV HARDIVASLI
AQKVTSSQAF QWLSQLRHCW YEQQHHCFVN ICDAQFLYSY EYLGNTPRLV ITPLTDRCYI
TLTQSLHLNM SGAPAGPAGT GKTETTKDLG RAMGVMVYIF NCSEQMDYKS IGNIYKGLAQ
TGAWGCFDEF NRISVDVLSV VAVQVKIIQD AIRSKKKRFL FLDKSIVLKA SVGIFITMNP
GYAGRTELPE NLKALFRPCA MVVPDTELIC EIMLVAEGFR SAKLLARKFI TLYSLCKEQL
SQQDHYDWGL RAVKSVLVVA GTLRRKDRSR PEDQVLMRAL RDFNMPKIVT EDVMIFLGLL
GDLFPGLEVE RERDFEFEKA IRKTAVELRL QPEETFILKV VQLEELMSVR HSVFVLGNAG
TGKSQILRVL HKTHANLKRK PVWNDLNPKA VDRDELFGFI HPATREWKDG LFSSLMREQA
NISHTGPKWI VLDGDIDPMW IESLNTVMDD NKVLTLASNE RVPLTSSMRL VFETSHLRMA
TPATVSRAGI LYINPQDLGW NPYVGSWIDQ RQHQTERAHL TILFEKYVPR CVEQMRNTFK
TITPIPENSM VQTLCTLLAC LLTPENIPAD APREVYETYF TFACIWAFGG ALHQDQLHDY
RAEFSQWWTK EMKTVKLPAQ GTVFDYYLDP QTRKFVPWSD VVPQFEMETG TPLQAVLVHT
AETVCLRYFM DLLLEMRQPL MLVGNAGVGK SALVRNKLEF LKESYMTTKV PFNYYTTSLM
LQAILERPLE KRAGRSYSPV GNRRMIYFID DLNMPAVDIY GTVQPHTLIR QHLDYGHWYD
RQKLTLKEIH NTQYVACMNP TAGSFHINPR LQRHFSVFAV NFPSFEAQSS IFSQILCGHL
KQQLFSVAVQ RSAAAVVQAA ITLHHKMVHS FLPTAIKFYY TFNLRDLSNI FQGILFAEPD
SMKESIDLAL LWLHESCRVY SDRLVDVTDL QLFRKLQMET ELKDTKVTKQ PLLYCHFAQM
GEEALYAPVT DWSTLKSILT DALESYNELN AAINLVLFED AMQHVCRISR ILESPRGHGL
LVGVGGSGKQ SLTRLAAYMS SVEVFQITLS KGYSMQDLKM DLAVLFIKTG VKNQRIALLL
TDAQIPDEQF LVIINDLLAS GEIPELFSEE EIEDIVSRVR AEVRTLGLLD NRENCWRFFT
DRVRQQLTVV LCLSPVGSAL RVRARRFPAL FQCTTIDWFH PWSSEALQSV SYRFIQEIEG
IEPAVQESIS LFMAYVHTSV NQASEKYQRN EKRYNYTTPK SFLQQITLYK NLLEKSRAQL
QLKMTRLDSG LQKLQTTATQ VEDLKAKLAS QEVELTLKKQ NIDALITKIG LQTERVSSKK
KDADVEAQKV AVIKAEVSAR QKDCENDLAK AEPSLTAATA ALHTLNKVNL TELKAFPNPP
AAVINVAAAV MVLLAPRGRV TKDRSWKAAR AFMGKVDDFL QALVSYDKEH IPESCLSVVK
QEYLRNPEFH PDLVRTKSTA AAGLCAWTIN IVRYYEIFCD VIPKRQALSQ ANVELEMATA
KLLAVQKKLV DLDASLQNLT TQFEKATAEK ISYQEEVTRT NQTIELANRL VKGLESEKER
WSQAVVQYEK QQTTLCGDVL IASAFVSYMG YFTRQYRLEV LNNAWIPFLQ TQKVSVPLTD
GLDPVLVLTD DATVAAWHNE GLPNDRMSTE NAAILTTSER WPLIIDPQQQ GIKWIRSRLG
PELRVVQLGQ GGYLEVIEQA LVCGETVLIE NLPEKVDPVL EPLLGRNTIK RGRYIKIGGK
ECEYNSNFRL IIHTKLANPH FPPELQAQTT LINFTVTPLG LEEQLLGQVV SCERPDLEAL
KMELTMQQNH FKIELKRLED DLLNRLSAAH GNFLGDISLV EQLESTKTTA THIQCKVVEA
RENETKINEA RELYRPAAER ASLLFFIIND LSKINLMYQF SLKSFNSVFS KAMERAEWDE
DVRARVHTLS EAITYSVFLY TSQGLFERDK LTFLSHTAFQ ILLKQGLIDA QEFDFLLRFP
VEPSRVTPVS FLSAHAWGAV KTVSTLEHFS GLDRDIESSP KRWRKIVESS CPEKERLPQD
WKNKSSFQKL IILRALRPDR MTYSLRNFVQ EIMGTKYVEA ARLEFDKLYE RSGPSTPVFF
ILSPGLDPLK DVEKLGLKLG FSIDQGTLHN VSLGQGQEEV AERVVKNASK LGNWVILQNV
HLVARWLPSL DALLQTAAVA CHPHYRAFIT GEPAPSPEQH IIPRGILENA IKITNEPPTG
MNASLHAALN NFSQDTLDQC TKEQEFNSMF FSLCFFHACV MERRKFGPQG WNHNYPFSTG
DLTICASVLY NYLEANTKVP WEDLCYLFGE VMYGGHITDD WDRTLCKTYL QEFMHPKMFE
GELCLCPGFL APQFTDYNGY HGYIDGHLPS ENPTLYGLHP NAELECLTVT SDNLLRTLLE
LQPQDSSKGD GAAQSTEEKV KVVVDDILDK LPEEYNMAEI VTKTTERSPY VLVCFQECER
MNLLLAEIRR SLDELDLGLK GELTTSSDME SLQSALFTDS VPASWARLAY PSTKPLAQWF
TDLTSSCREL DSWTQDLVLP AVVWLSGLFN PQSFLTAVLQ SIAHKNQWPL DKMTLTVDIT
KKTKDDFGHP PREGAYIHGL FMEGASWDIQ SGVISEAILR DLTPAMPVLY VRAVPAEEQE
LKNTYKCPVY RTKQRGPTYV WTLHLRTKQP PAKWILAGVA LLLSV
//
