ID A0A3Q3VMW9_MOLML Unreviewed; 1496 AA.
AC A0A3Q3VMW9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000003046.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000003046.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR STRING; 94237.ENSMMOP00000003046; -.
DR Ensembl; ENSMMOT00000003094.1; ENSMMOP00000003046.1; ENSMMOG00000002448.1.
DR OMA; TAGQHRE; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd08691; C2_NEDL1-like; 1.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037795; C2_HECW.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR040524; HECW1_helix.
DR InterPro; IPR032348; HECW_N.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR11254:SF127; E3 UBIQUITIN-PROTEIN LIGASE HECW2; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF18436; HECW1_helix; 1.
DR Pfam; PF16562; HECW_N; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 187..318
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 732..765
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 909..942
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 1161..1496
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1464
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1496 AA; 166409 MW; 681C59BB9A44A0CC CRC64;
MAATASSSSS SPSASSSANG SAREQLLAVR RRTPHSRPYT IGPDNLRSLS AQGDQPEATG
VALPRANSDT DLVTSDSRSS LTASTYQLTL GHSHLVISWD IKEEVDATDW IGLYHIDETC
VANVWDSKNR GVNGTQRGQI VWRLEPGPYF MEPETKVCFK YYHGVSGALR ATTPCITVKN
PGVLVGSEGQ VEDQSGTEHC RKLVSFTLSD IRAVGLKKGM FFNPDPYLKM SIQPGKRSGL
PKFTHHGQER RSSIIANTTN PVWHGEKYTF VALMNDVLEI EVKDKFAKSR PIIKRFLGQL
IIPVQRLLEG DQPVSYSLCR RLPTDHVSGM LLFRVDITST GQEEASPDAV GTILGGAVNG
DPGSPSDDED LPHPSSSSRV TCGASPTGSD EGSIIVNGAC YYGEDSVWRE PGQMGEESQL
PVALGSHTHR QVSLNDYLDA IETPRSPGDR PLVGPLPKLR SSFPTDTRLN AMLHIDSDED
EESAGQHREQ SQEARTQQSA DLSGSESSKA EPQRQTGATT EAGSSGSEPS GPEPGDQTQG
STAGTAEAPQ ATGGTSTAST SSQVSEGEAA TAAPGSGASM EECTRQEQRR DAPCTSSLGP
LSPIQVSSCT VRILECKYFH LQYFPPFQEV ETNKEVAPKA EEEGAESSSS EANGPVAGNP
RTISVNADRG GGTPEVGRLK LLPFQGDATG LPTSHFDAII FACATAQVNG HQSVRSSPSV
RHEISRYQRV EEPLPPNWEA RIDSHGRIFY VDHVNRTTTW QRPTAPPAPQ TLQRSNSIQQ
MEQVRPYQSI RRTITSDNRL EEQPANELPA DETDAQPSIP ELRRDNSVAQ SSSRSRLTLL
LQSPSAKFLT SPDFFTVLHS NPGAYRMFTT NTCLKHMISK VRRDAHHFER YQHNRDLVAF
LNMLANKQLE LPRGWEMKHD HTGKPFFVDH NCRATTFIDP RLPLQSTRPP SLLAHRQHLT
RQRSHSAGEV SEDPRHAGPP VLPRPSSTLT SASRGQCQDV VPVAYNDKIV AFLRQPNIFE
ILQERQPDLS RNHSLREKVQ VIRTDGGSGL ARLSGDADLV MLLSLFEDEV MSYVPPHALL
HPSYCQSPRG SPVSSPQNSP GTQRANARAP APYKRDFEAK LRNFYRKLET KGYGQGPGKL
KLIIRRDHLL EDAFNQIMCY SRKDLQRSKL YVSFVGEEGL DYSGPSREFF FLVSRELFNP
YYGLFEYSAN DTYTVQISPM SAFVDNHHEW FRFSGRILGL ALIHQYLLDA FFTRPFYKGL
LRIPCDLSDL EYLDEEFHQS LQWMKDNDIE DMLDLTFTVN EEVFGQITER ELKPGGANIP
VSEKNKKEYI ERMVKWRIER GVVQQTESLV RGFYEVVDAR LVSVFDAREL ELVIAGTAEI
DLSDWRNNTE YRGGYHDNHI VIRWFWAAVE RFNNEQKLRL LQFVTGTSSI PYEGFASLRG
SNGPRRFCVE KWGKVTSLPR AHTCFNRLDL PPYPSFSMLY EKMLTAVEET STFGLE
//
