ID A0A3Q3VS04_MOLML Unreviewed; 768 AA.
AC A0A3Q3VS04;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000001312.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000001312.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR AlphaFoldDB; A0A3Q3VS04; -.
DR STRING; 94237.ENSMMOP00000001312; -.
DR Ensembl; ENSMMOT00000001340.1; ENSMMOP00000001312.1; ENSMMOG00000001103.1.
DR OMA; EDMNKCS; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 50..148
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 87466 MW; 5A2F06F6A68D230F CRC64;
RVYGESSHKA MTSPSPTHSV SSSSSKHDSN QDSWEIVEGL KGVLASMQEP DRQEGFLLKK
RKWPMKGWHK RYFVLERGIL TYTKRAIDVC ITTRAKLHGC IDVGLSVMSI KKKAMCIDLD
TEDNIFHLKV KSPELFEEWV SKLRHHRVFR QNEIAMYPHE RHLFHPHSSS SPSLNDSLRK
VDLQECESYL LELNLLLKSM ELFHRTYSAP AISALQIPSC ISSQSPHLHA SNPNLSTSDS
NTQEVCPESP DSPTDVSQLQ EDFCRLANNI HATLKSTFSS LVAERDRLRL TIDMQVPQPA
QVVGLKTAYA SVRGSNSLVH QVSNDSKASI PESISEFFDA QEYLISSSSS ENEVSDDDSY
ISDVSDSISM DTFSNEGGSE RHNSVSSVVT HARRRSTLPS PRPSSSVSLW NILKNNIGKD
LSKVSMPVQL NEPINTLQRL CEELEYSELL DTANQTHDPY QRMVYVATFA ISAYASTYHR
AGSKPFNPVL GETYECDRPD KNLRFIAEQV SHHPPVSACH SESLNFTFWQ DVRWKNKFWG
KSMEIVPMGT THLTLPAFGD HYEWNKVTSC IHNILSGQRW IEHYGEMSIK NVNSDACQCK
ITFVKANSWS STVNEIEGVV TDSKGKVVHS IFGKWHESIF QGDPPSATCT WRANPMPVDQ
EQYYGFTQFA MELNELDATL RLLLPPTDTR FRPDQRLLED GNTEGAEEQK QRIEQLQRER
KKVLQDNNMT HLPRFFKKCN NDTWVSNNTY WELRKDPGFS KMDFPVLW
//
