ID A0A3Q3VWA2_MOLML Unreviewed; 282 AA.
AC A0A3Q3VWA2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=pancreatic elastase {ECO:0000256|ARBA:ARBA00039015};
DE EC=3.4.21.36 {ECO:0000256|ARBA:ARBA00039015};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000007266.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000007266.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins, including elastin. Preferential
CC cleavage: Ala-|-Xaa.; EC=3.4.21.36;
CC Evidence={ECO:0000256|ARBA:ARBA00036864};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
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DR AlphaFoldDB; A0A3Q3VWA2; -.
DR STRING; 94237.ENSMMOP00000007266; -.
DR Ensembl; ENSMMOT00000007401.1; ENSMMOP00000007266.1; ENSMMOG00000005404.1.
DR OMA; KQGCNVS; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24257; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR24257:SF0; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 1; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..282
FT /note="pancreatic elastase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018652823"
FT DOMAIN 34..270
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 282 AA; 30999 MW; 5465F5AFB2ED13B0 CRC64;
MLRFLLLTSL AALVLAELRP EPRYLEDDAV EERVVGGEVA RANSWPWQIS LQYKSGSNYY
HTCGGTLIKR GWVMTAAHCV DRSRTWRVVL GDHNINTHEG REQYMSVSRV YIHPNWNTNN
VAGGWDIALL RLSSEATLNN YVQLATLPPS NQVLPHNNPC YITGWGRTQT GGQLSAQLKQ
ASLPVVDHNT CSSYGWWGST VKSSMVCAGG YSESGCQGDS GGPLNCSVNG KWVVHGVTSF
VSASGCNAYK KPTVFTRASA YISWMNSVST ITHPHEPKGC KF
//