ID   A0A3Q3VZL7_MOLML        Unreviewed;       702 AA.
AC   A0A3Q3VZL7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE            EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000004592.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000004592.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR   AlphaFoldDB; A0A3Q3VZL7; -.
DR   Ensembl; ENSMMOT00000004676.1; ENSMMOP00000004592.1; ENSMMOG00000003656.1.
DR   OMA; LFFGHQR; -.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd06203; methionine_synthase_red; 1.
DR   Gene3D; 3.40.50.360; -; 1.
DR   Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   InterPro; IPR003097; CysJ-like_FAD-binding.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR001094; Flavdoxin-like.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR   PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR   Pfam; PF00667; FAD_binding_1; 1.
DR   Pfam; PF00258; Flavodoxin_1; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PRINTS; PR00369; FLAVODOXIN.
DR   PRINTS; PR00371; FPNCR.
DR   SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR   SUPFAM; SSF52218; Flavoproteins; 1.
DR   SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   FMN {ECO:0000256|ARBA:ARBA00022643};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620}.
FT   DOMAIN          7..150
FT                   /note="Flavodoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50902"
FT   DOMAIN          271..532
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51384"
SQ   SEQUENCE   702 AA;  77895 MW;  A8B682070924015E CRC64;
     MYLKRRFVLL YGSQKGQAQS IAEGVAEEAG DHGLVAELSC LDNSEKYNLE KETAPVVFIV
     STTGDGEPPD NALGFVKRIK RKTLASDHYK HLCYALLALG DTNYANFCNC GKTIEQRLQE
     LGAKQFYPTG YADDGVGLEV VVDPWLDGLW EAIKEALSKM TSDSTGYLNV DAGASPKETA
     DSSPPDIQLN LLSITDCQNC ELSEQSRKTL STSSASATQT AASSLTHSLP PLSELALNVP
     LLPPPYLDVS LQEAETTEQV SIRIVGPFKK ENLHEVPISK AVQMTRGDSV KTALLLELDI
     SACPMMTYQP GDSFDVFCSN RATEVEDMLH RLGLYDKRNH MVHICLLKDT KKRGAQVPSY
     IPQNISLLYL LTWCLEIRSV PKKAFLRALL EHTADGVQRR RLQELCSKQG AADYNLYVRD
     PSLSVLELLT AFPSCSPPLS ILIEHVPKLQ PRPYSAASSC RRHPGKLHFV FNLVELPACS
     VRPVWRRGLC TGGLFDLINP VLVFPGKTES SSKAALPKIH VSWRPSCSFR PPADLSVPFI
     MVGPGTGVAP FIGFLQQRYG KQEHPEATFG ETWLFFGCRH RDRDYLFREE LEGFVSSGTL
     NHLKLCFSRD GHEEDADGAT DSVTRCRYVQ HNLLCNSQSI TDILLKQNGR LYVCGDAKNM
     AKDVNDALVE MMKTALGRDQ LEAMKTLAAL REDKRYLQDI WG
//