ID A0A3Q3W1V0_MOLML Unreviewed; 997 AA.
AC A0A3Q3W1V0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMOP00000007938.1};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000007938.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000007938.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC {ECO:0000256|ARBA:ARBA00006919}.
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DR AlphaFoldDB; A0A3Q3W1V0; -.
DR STRING; 94237.ENSMMOP00000007938; -.
DR Ensembl; ENSMMOT00000008087.1; ENSMMOP00000007938.1; ENSMMOG00000006172.1.
DR OMA; CISRKIR; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF51; RAS AND RAB INTERACTOR 2; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 121..215
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 720..860
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT DOMAIN 890..981
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 243..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..395
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 111449 MW; 0D544167212F2013 CRC64;
MGTVQLELVI ANEAYLQYFV YCCSPSSRNF PSPAKASYSV FFQLIDTFAL EIGELKKEMV
QSSPTVDTEL MDQQGLESEV SGVYLQSPCC GRVGLERDSG YDSLRRRMSV LDRLTQTHPV
WLLLAVSEQE AIHILLKQPP GVFLVRKSAA LQRKVLSVRV REDESGAAIS HFPVRENQYT
FSLEGSGISF ADLFRLVAFH CISRDVLPFT LKLPEAIASA KTQKELEEVA QLGAGRFWDS
ALCSQGRSSP RPRRPLSRTL SPQRTYRNRE DSQQRQAGTH CDSAPPTLRP QTSPASFHLE
RRHSSGPLCI VNPLFIQTHR HHHHCEDGLS PYAVKSDNGP EKALKTSVIQ VSDHLLDKIK
LNSKSQPRPP RPPPPRSMPR RRPAPPPPGP PAATTRPKRM PEAIAATAKQ RQSSYKRPAP
PRPPMGSKHG GPSKTASSPI PVPSNLPPPR PKKPDLEDQR CHIALDDETI AKALSRAKLS
PCQPPPAAPA DILLEDNSGS LSVPKERGRQ RLSDTSMSTS SSDSLEYSQS PGFSLGLAAS
PSREDEDDGE EDEDEDYGVG LEADLEMRLR PSFKAQRRKV GVSLGGGSFI LPRGLKGQFR
KVSGMLSSLV TPERRAVKRI AELSRDKSSY FGSLVQDYIS FVQENRGCHT SGMDFLQTLR
QFMTQMKAYL RQSSELNPPI ESLIPEDQID QVLEKAMHKC VLKPLKSDIE VALHDFQVSS
GAWQQLKENL ALAKTKKPQE LGVDGAVPPD PMAVEKIRHK FLRMRKVYSP EKKVSLLLRV
CKLIYTIMQD NSGRMYGADD FLPMLTYVVA QCDMPQLDTE IQYMMELLDP SLLQGEGGYY
LTSAYGAMAL IKNFQEEQAA RVLSSEARNT LHQWHYRRTA QRSVPSVDDF QNYLRVALQE
VDMGCTAKTL VVHPYTTTEE VCSLCAYKFN IPDPENYALF LVTQETSQQL APDTHPQRIK
AELHSRPQTQ TFHFLYRKVP NLHLCIPADM HNGNCLS
//
