ID A0A3Q3W284_MOLML Unreviewed; 1091 AA.
AC A0A3Q3W284;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Upf1 domain-containing protein {ECO:0000259|PROSITE:PS51997};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000010211.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000010211.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR AlphaFoldDB; A0A3Q3W284; -.
DR STRING; 94237.ENSMMOP00000010211; -.
DR Ensembl; ENSMMOT00000010392.1; ENSMMOP00000010211.1; ENSMMOG00000007881.1.
DR OMA; TDRGQHG; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 94..251
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 102..134
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 116..144
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 162..192
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 975..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 120981 MW; FDA718F9FD2060EC CRC64;
MSVEAYGPSS QTLTFLDTEE TELLGADTQG SEYDFTDFTL PSQTQTQGQT QSQLDNQVRL
NNGLLQNGDD PVVKASQLLA ELNFEEDEED TYYTKDLPAH ACSYCGIHDP ACVVYCNTSK
KWFCNGRGNT SGSHIVNHLV RAKSKEVTLH KDGPLGETVL ECYNCGCRNV FLLGFIPAKA
DSVVVLLCRQ PCASQSSLKD INWDSSQWQP LIQDRCFLSW LVKIPSEQEQ LRARQIAAQQ
INKLEELWKE NPTATLEDLE KPGVDEEPQH VLLRYEDAYQ YQNIFGPLVK LEADYDKKLK
ESQTQDNITV RWDLGLNKKR IAYFTLPKTD SDMRLMQGDE ICLRYKGDLA PPWKGIGHVI
KVPDNYGDEI AIELRSGAGA PVEIPHNFQV DFVWKSTSFD RMQSALKTFA VDETSVSGYI
YHKLLGHEVE DVVIKCQLPK RFTAQGLPDL NHSQVYAVKT VLQRPLSLIQ GPPGTGKTVT
SATIVYHLAR QGNGPVLVCA PSNIAVDQLT EKIHQTGLKV VRLCAKSREA IDSPVSFLAL
HNQTRNMDSM PELQKLQQLK DETGELSSSD EKRYRALRRT AERELLMNAD VICCTCVGAG
DPRLAKMQFR SILIDESTQA TEPECMVPVV LGAKQLILVG DHCQLGPVVM CKKAAKAGLS
QSLFERLVVL GIRPIRLQVQ YRMHPSLSAF PSNIFYEGSL QNGVTAAERV KKGFDFQWPQ
PDKPMFFYVT QGQEEIASSG TSYLNRTEAA NVEKITTRLL KAGAKPDQIG IITPYEGQRS
YLVQYMQFSG SLHTKLYQEV EIASVDAFQG REKDFIILSC VRANEHQGIG FLNDPRRLNV
ALTRARYGVI IVGNPKALSK QPLWNHLLNY YKEQKVLVEG PLNNLRESLM QFSKPRKLVN
TINPGGRFMS TAMYDAREAL IPGSVYDRSN SGRTSNMYFQ THDQIGMIGT GPNPMTSMNI
PIPFNLVMPP IPPPGYMGQV NGPTSGRGGG MKGKAGSGGG GGTRGGHMSG SQASQDLGSQ
PFSQGPLTQG YIGMSQPSQM SQPGLSQPEL SQDSYLGDEF KSQIDMALSQ DSTYQGERAY
QHGGVTGLSQ Y
//
