ID A0A3Q3W2A2_MOLML Unreviewed; 1082 AA.
AC A0A3Q3W2A2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=HMG box domain-containing protein {ECO:0000259|PROSITE:PS50118};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000010231.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000010231.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q3W2A2; -.
DR STRING; 94237.ENSMMOP00000010231; -.
DR Ensembl; ENSMMOT00000010411.1; ENSMMOP00000010231.1; ENSMMOG00000007869.1.
DR OMA; NAWFPIC; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21993; HMG-box_WDHD1; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR048591; Ctf4-like_C.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022100; Mcl1_mid.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19932; WD REPEAT AND HMG-BOX DNA BINDING PROTEIN; 1.
DR PANTHER; PTHR19932:SF10; WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF20946; Ctf4_C; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12341; Mcl1_mid; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 9..41
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 132..173
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 233..267
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 997..1043
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 997..1043
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 304..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1082 AA; 119247 MW; 7F8B4BAB027E400A CRC64;
MPCERKPMRY GHSEGHTEVC FDDTGKFIVT CGNDGDVRIW EGLDDDDPKF ITVGEKVYSL
ALKNSKLVMA SSNNTVQIHT FPDGDPDGIL TRFTTNATHV TFNSSGSRVA AGSSDFLVKV
VEVSDSSQQK TLRGHEAPVL SVAFDPKDVF LASASCDGSV VVWSIEEQTQ VISWPLLQKT
NDVSNAKSLC RLAWQPGAAK LLAVPVETKV HLYERGSWDH VSTLSDDLLI QPINVVTWSP
CGQFLAAGSV GGSMTVWDVK SKLCVERQKH EKGFTVCCLA WHPSGSQIAY TDTEGRLGLL
DGLSSSNTDT LKAPTKPAAK EYDDLFDDDD DRLMDEGLSD TNSPVKKAAA GDEDDDDDNI
LLPATGRVRN RGAILDDENS LGSLRLGQDE FGDDDAGSAV GPETVPLVPS RPVYEGPLPT
LPQKAFQPGS TPAHLTHRFM MWNSVGIVRS YNDEQDNAID VEFHDTAVHH AMHLTNSLGH
TMADLSQEAV LLACPSTDEL ASKLQCLHFS SWDTNKEWMV DLPQGEDAKA LCLGQGWAAV
ATTALMLRLF SIGGVQRELF SLPGPVVCMV GHGEQLLIVY HRATGFDGEQ ALGVQLLQFG
QRKRQLITGE PLPLSRRSYL SWLGFTAEGQ FVKRRFSGLR DRSCIRFLFW ILKETCKSKS
DHYWVVGVHE NPQQLRCIPC KGSRYPPTLP RPAVAILPFK LPLCQTSTEK GQMEEQYWRS
VLFHSHYGFL LSSGYEIDEQ AQSQSQKEQQ ELLMKMFALS CKLEREFRCL ELAELMTHNV
VPLAIRYASR SRRMALAERL SELAREKANQ IQEEVQEEEE PEYSRRASGN RRNQEEEGGQ
EAELKEIEDA QEMMATEEAA ESRKGQLHPF SSACFFLSTG RCSNMSDACV STAGVTPFVQ
SSGKSSASSA QPRATNILDN MTASKKLGPL SGSSAKPNKG PILKPLAPRP KTKTQSTLLQ
LTATKTASKK EKAESTADQQ KQPDVSAPTL PADDTENKRP RTGFQLWLEE NRKSITADHP
DLEETDVIKE AMGRFRTLSA EERLVRSTEG GDGRADAEES GAKKKKPLDT SSKLSAFAFN
KS
//
